ID H9C3E0_MISAN Unreviewed; 490 AA.
AC H9C3E0;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Transcription factor SOX-10 {ECO:0000256|ARBA:ARBA00040805};
GN Name=Sox10 {ECO:0000313|EMBL:AFD97052.1};
OS Misgurnus anguillicaudatus (Oriental weatherloach) (Cobitis
OS anguillicaudata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cobitidae; Cobitinae; Misgurnus.
OX NCBI_TaxID=75329 {ECO:0000313|EMBL:AFD97052.1};
RN [1] {ECO:0000313|EMBL:AFD97052.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:AFD97052.1};
RX PubMed=23535997; DOI=10.1007/s10695-013-9788-4;
RA Xia X., Nan P., Zhang L., Sun J., Chang Z.;
RT "Homologue of Sox10 in Misgurnus anguillicaudatus: sequence, expression
RT pattern during early embryogenesis.";
RL Fish Physiol. Biochem. 39:1341-1351(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JQ217144; AFD97052.1; -; mRNA.
DR AlphaFoldDB; H9C3E0; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22031; HMG-box_SoxE; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR022151; Sox_N.
DR PANTHER; PTHR45803; SOX100B; 1.
DR PANTHER; PTHR45803:SF6; TRANSCRIPTION FACTOR SOX-10; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12444; Sox_N; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}.
FT DOMAIN 108..176
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 108..176
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 51771 MW; F2DEAD184B0A50A5 CRC64;
MSTEEHSLSE VEMSPGVSDD GHSMSPGHSS GAAGGPDSPL PCQPSQMSGV GEEVAGVSGG
VSVKSDDEDD RFPIGIREAV SQVLNGYDWT LVPMPVRVNS GSKSKPHVKR PMNAFMVWAQ
AARRKLADQY PHLHNAELSK TLGKLWRLLN EADKRPSIEE AERLRKQHKK DYPEYKYQPR
RRKNGKLGTN SETDGHSEGE VSHSQSHYKS LHLEVAHGAG SPLGDGHHPH ATGQNHSPPT
PPTTPKTELQ GGKSGEGKRE GGAGGSRGGL GVGADGSSSS ASGSSKPHID FGNVDIGEIS
HDVMANMEPF DVNEFDQYLP PNGHPGVAQA SGGTGSGSSA SPYTYGISSA LAAASGHSTA
WLSKQQLPSQ QHLGSDGGKT QIKSEAHFSS EAAASASGSH VTYTPLSLPH YSSAFPSLAS
RAQFAEYADH QASGSYYAHS GQTSGLYSAF SYMGPSQRPL YTAIPDPGSV PQSHSPTHWE
QPVYTTLSRP
//
