ID H9CXT8_SCHMD Unreviewed; 547 AA.
AC H9CXT8;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
OS Schmidtea mediterranea (Freshwater planarian flatworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Seriata; Tricladida; Continenticola; Geoplanoidea;
OC Dugesiidae; Schmidtea.
OX NCBI_TaxID=79327 {ECO:0000313|EMBL:AFD29609.1};
RN [1] {ECO:0000313|EMBL:AFD29609.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CIW4 {ECO:0000313|EMBL:AFD29609.1};
RX PubMed=22385657; DOI=10.1016/j.stem.2012.01.016;
RA Wagner D.E., Ho J.J., Reddien P.W.;
RT "Genetic Regulators of a Pluripotent Adult Stem Cell System in Planarians
RT Identified by RNAi and Clonal Analysis.";
RL Cell Stem Cell 10:299-311(2012).
CC -!- SIMILARITY: Belongs to the DEAD box helicase family.
CC {ECO:0000256|RuleBase:RU000492}.
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DR EMBL; JQ425141; AFD29609.1; -; mRNA.
DR AlphaFoldDB; H9CXT8; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47959:SF13; ATP-DEPENDENT RNA HELICASE RHLE; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000492};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU000492};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU000492};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000492}.
FT DOMAIN 121..149
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 152..333
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 357..505
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 121..149
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT COMPBIAS 17..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 61443 MW; 6D9820FF2CE8F8F1 CRC64;
MDTSKFNGIG RGRGRRLNNV VSNSPSSHTY NNGVDNEELS FDKLSLNDNK ENFSQSVREF
SNNRVKIIED GDISMAVQRV NYIPDDNAED YQLHVNSGIN FDNYDNVQVH VTGRNIPEAI
TSIEDFQIPE FLRLNIKSSD YKKLTPVQKY TIPMINSDRD LMACAQTGSG KTMAFLVPII
KNISENPDTS SSGKNSPKCL IVVPTRELCR QIFTVAHRLC KDSSVKCSYS YGGVEMRTSM
MKLYKCDILV STPGRLVANL ESAAISLDKI RYLVLDEADR LLQNEKFMES IKLVYEKSKL
VGVDKFHVSM FSATFPAEIQ QLGESLLSDH LFVAVGLVGA ANTDIKQTVL QVNSHDKLNA
SLEYLTNNKT GKTLVFVQAK RFADFLGIRL IDLNLLATTI HGDRDQAARE SALNDFKSGR
VNFLVATDVA SRGLDIPKVD TVINIDMPED MDVYIHRIGR TGRCGNPGLS VSFFDEEKDI
ALAPRLVKIL NESGQECPDW LHSLCSGYRP FEHGRNRKDY RQNVESSTFV EKKKFMNASD
EQDDFFN
//
