ID H9ERL4_MACMU Unreviewed; 456 AA.
AC H9ERL4;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 22-FEB-2023, entry version 38.
DE SubName: Full=Rap guanine nucleotide exchange factor-like 1 {ECO:0000313|EMBL:AFE65023.1};
GN Name=RAPGEFL1 {ECO:0000313|EMBL:AFE65023.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:AFE65023.1};
RN [1] {ECO:0000313|EMBL:AFE65023.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Caudate {ECO:0000313|EMBL:AFE65023.1};
RX PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., Pandey S.,
RA Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., Tharp G.K.,
RA Marcais G., Roberts M., Ferguson B., Fox H.S., Treangen T., Salzberg S.L.,
RA Yorke J.A., Norgren R.B.Jr.;
RT "A new rhesus macaque assembly and annotation for next-generation
RT sequencing analyses.";
RL Biol. Direct 9:20-20(2014).
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DR EMBL; JU321267; AFE65023.1; -; mRNA.
DR AlphaFoldDB; H9ERL4; -.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF230; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR-LIKE 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 2: Evidence at transcript level;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 218..454
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 456 AA; 52311 MW; 46F60AF1A0273CD5 CRC64;
MEGPEGLGQK QACLAMLLHF LDTYQGLLQE EEGAGHIIKD LYLLIMKDES LYQGLREDTL
RLHQLVETVE LKIPEESQPP SKQVKPLFRH FRRIDSCLQT RVAFRGSDEI FCRVYMPDHS
YVTIRSRLSA SVQDILGSVT EKLQYSEEPA GREDSLILVA VASSGEKVLL QPTEDCVFTT
LGINSHLFAC TRDSYEALVP LPEEIQVSPG DTEIHRVEPE DVANHLTAFH WELFRCVHEL
EFVDYVFHGE RGRRETANLE LLLQRCSEVT HWVATEVLLC EAPGKRAQLL KKFIKIAALC
KQNQDLLSFY AVVMGLDNAA VSRLRLTWEK LPGKFKNLFR KFENLTDPCR NHKSYREVIS
KMKPPVIPFV PLILKDLTFL HEGSKTVVDG LVNIEKLHSV AEKVRTIRKY RSRPLCLDME
ASPHHLQTKA YVRQFQVIDN QNLLFELSYK LEANSQ
//
