ID H9FJG0_MACMU Unreviewed; 639 AA.
AC H9FJG0;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Potassium voltage-gated channel subfamily H member 2 {ECO:0000256|ARBA:ARBA00013838};
DE AltName: Full=Ether-a-go-go-related gene potassium channel 1 {ECO:0000256|ARBA:ARBA00030015};
DE AltName: Full=Voltage-gated potassium channel subunit Kv11.1 {ECO:0000256|ARBA:ARBA00031970};
DE Flags: Fragment;
GN Name=KCNH2 {ECO:0000313|EMBL:AFE74769.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:AFE74769.1};
RN [1] {ECO:0000313|EMBL:AFE74769.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Caudate {ECO:0000313|EMBL:AFE74769.1};
RX PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., Pandey S.,
RA Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., Tharp G.K.,
RA Marcais G., Roberts M., Ferguson B., Fox H.S., Treangen T., Salzberg S.L.,
RA Yorke J.A., Norgren R.B.Jr.;
RT "A new rhesus macaque assembly and annotation for next-generation
RT sequencing analyses.";
RL Biol. Direct 9:20-20(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel family. H (Eag) (TC
CC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
CC {ECO:0000256|ARBA:ARBA00007076}.
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DR EMBL; JU331013; AFE74769.1; -; mRNA.
DR AlphaFoldDB; H9FJG0; -.
DR HOGENOM; CLU_005746_2_0_1; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR003967; K_chnl_volt-dep_ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR10217:SF506; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 2; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01470; ERGCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 136..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 466..566
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFE74769.1"
FT NON_TER 639
FT /evidence="ECO:0000313|EMBL:AFE74769.1"
SQ SEQUENCE 639 AA; 71470 MW; 9A1C1F1812FD66FA CRC64;
ASVRRASSAD DIEAMRAGAL PPPPRHASTG AMHPLRSGLL NSTSDSDLVR YRTISKIPQI
TLNFVDLKGD PFLASPTSDR EIIAPKIKER THNVTEKVTQ VLSLGADVLP EYKLQAPRIH
RWTILHYSPF KAVWDWLILL LVIYTAVFTP YSAAFLLKET EEGPPATECG YACQPLAVVD
LIVDIMFIVD ILINFRTTYV NANEEVVSHP GRIAVHYFKG WFLIDMVAAI PFDLLIFGSG
SEELIGLLKT ARLLRLVRVA RKLDRYSEYG AAVLFLLMCT FALIAHWLAC IWYAIGNMEQ
PHMDSRIGWL HNLGDQIGKP YNSSGLGGPS IKDKYVTALY FTFSSLTSVG FGNVSPNTNS
EKIFSICVML IGSLMYASIF GNVSAIIQRL YSGTARYHTQ MLRVREFIRF HQIPNPLRQR
LEEYFQHAWS YTNGIDMNAV LKGFPECLQA DICLHLNRSL LQHCKPFRGA TKGCLRALAM
KFKTTHAPPG DTLVHAGDLL TALYFISRGS IEILRGDVVV AILGKNDIFG EPLNLYARPG
KSNGDVRALT YCDLHKIHRD DLLEVLDMYP EFSDHFWSSL EITFNLRDTN MIPGSPGSAE
LEGGFSRQRK RKLSFRRRTD KDTEQPGEVS ALGPGRAGA
//
