ID H9FW52_MACMU Unreviewed; 1048 AA.
AC H9FW52;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=OTUD4 {ECO:0000313|EMBL:AFE78861.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:AFE78861.1};
RN [1] {ECO:0000313|EMBL:AFE78861.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Caudate {ECO:0000313|EMBL:AFE78861.1};
RX PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., Pandey S.,
RA Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., Tharp G.K.,
RA Marcais G., Roberts M., Ferguson B., Fox H.S., Treangen T., Salzberg S.L.,
RA Yorke J.A., Norgren R.B.Jr.;
RT "A new rhesus macaque assembly and annotation for next-generation
RT sequencing analyses.";
RL Biol. Direct 9:20-20(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR EMBL; JU335108; AFE78861.1; -; mRNA.
DR AlphaFoldDB; H9FW52; -.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.90.70.80; -; 1.
DR InterPro; IPR003323; OTU_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR PANTHER; PTHR12419; OTU DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12419:SF9; OTU DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF02338; OTU; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50802; OTU; 1.
PE 2: Evidence at transcript level;
FT DOMAIN 1..90
FT /note="OTU"
FT /evidence="ECO:0000259|PROSITE:PS50802"
FT REGION 257..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 848..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..383
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..468
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..934
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..967
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 968..986
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1048
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1048 AA; 117006 MW; EB3BE57E0D075D1D CRC64;
MACIHYLREN REKFEAFIEG SFEEYLKRLE NPQEWVGQVE ISALSLMYRK DFIIYREPNV
SPSQVTENNF PEKVLLCFSN GNHYDIVYPI KYKESSAMCQ SLLYELLYEK VFKTDVSKIV
MGLDTLEVAD EDNSEISDSE DDSCKSKTAA AADVNGFKPL SDNEQLKNNG NSTSLPLSRK
VLKSLNPSVY RNVEYEIWLK SKQAQQKRDY SIAAGLQYEV GDKCQVRLDH NGKFLNADVQ
GVHSENGPVL VEELGKKHTS KNLKAPPPES WNTVSGKKMK KPSTSGQNFH SDMDYRGPKN
PSKPIKAPSA LPPRLQHPSG VRQHAFSSHS SGSQSQKFSS EHKNLSRTPS QIIRKPDRER
VEDFDHTSRE SNYFGLSPEE RREKQAIEES RLLYEIQNRD EQAFPALSSS SVSQSASQSS
NPCVQRKSSH VSDRKGSRRR MDTEERKDKD SIHGHSQLDK KPEPSTLENI TDDKYATVSS
PSKSKKLECP SPAEQKPAEH VSLSNPAPLL VSPEVHLTPA VPSLPATVPA WPSEPTTFGP
TGVPAPIPVL SVTQTLTTGP DSAVSQAHLT PSPVPVSIQA VNQPLMPLPQ TLSLYQDPLY
PGFPCNEKGD RAIVPPYSLC QTGEDLPKDK NILRFFFNLG VKAYSCPMWA PHSYLYPLHQ
AYLAACRMYP KVPVPVYPHN PWFQEAPAAQ NESDCTCTDA HFPMQTEASV NGQMPQPEIG
PPTFSSPLVI PPSQVSESHG QLSYQADLES ETPGQLLHAD YEESLSGKNM FPQPSFGPNP
FLGPVPIAPP FFPHVWYGYP FQGFIENPVM RQNIVLPSDE KGELDLSLEN LDLSKDCGSV
STVDEFPEAR GEHVHSLPEA SVSSKPEEGR TEQSSQTRKA DMALASVPPV AEGKAHPPTQ
ILNRERETVP VELEPKRTIQ SLKEKTEKVK DPKTAADVVS PGANSVDSRV QRPKEESSED
ENEVSNILRS GRSKQFYNQT YGSRKYKSDW GYSGRGGYQH VRGEESWKGQ PSRSRDEGYQ
YHRNVRGRPF RGDRRRSGMG DGHRGQHT
//
