ID   H9G3P6_ANOCA            Unreviewed;       576 AA.
AC   H9G3P6;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=WSC domain-containing protein {ECO:0000259|PROSITE:PS51212};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000000393.3, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000000393.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000000393.3};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000000393.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at
CC       the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
CC       as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.
CC       {ECO:0000256|ARBA:ARBA00035001}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004606}.
CC   -!- SIMILARITY: Belongs to the WSCD family.
CC       {ECO:0000256|ARBA:ARBA00010236}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; H9G3P6; -.
DR   STRING; 28377.ENSACAP00000000393; -.
DR   Ensembl; ENSACAT00000000410.4; ENSACAP00000000393.3; ENSACAG00000000404.4.
DR   eggNOG; KOG4157; Eukaryota.
DR   GeneTree; ENSGT00940000158096; -.
DR   HOGENOM; CLU_029239_1_0_1; -.
DR   InParanoid; H9G3P6; -.
DR   TreeFam; TF324060; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000000404; Expressed in testis and 7 other cell types or tissues.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   InterPro; IPR002889; WSC_carb-bd.
DR   PANTHER; PTHR45964:SF5; WSC DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR45964; WSCD FAMILY MEMBER CG9164; 1.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   Pfam; PF01822; WSC; 1.
DR   SMART; SM00321; WSC; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51212; WSC; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT   DOMAIN          240..335
FT                   /note="WSC"
FT                   /evidence="ECO:0000259|PROSITE:PS51212"
SQ   SEQUENCE   576 AA;  66062 MW;  69D6F1E8D57F3537 CRC64;
     MAKPFSRPQK FLWRTQFLLF FLTAAYLMAG SLLLLQRSRL VLQQGSRGTS GNQALPAAEM
     FSPARDTETR PVQNPHLTPK LIVNMDMLHG PTPDQKYGPR WLISRNSELR QLRRRWFLRF
     VNEQEPMQGA GAKVAKRAQE NKGTYIGCFD DDPREKMMKG AVFYDLRKMT IPHCQEACLN
     CYSTTVFPCY NNRCAQSPVI CVSSCFCLVS GGSRCNHLYH TCSEACGGKS GGKWRWTGRH
     AIYRGCFRAP ENLTNILPAV LIHLNLTVEM CSGFCSKKEF PLAVLRGSRC HCGFPTIHFP
     LRNNSDKSLC IPSQNTSTVA ERSRGKDYWL VYQTPVQDTR CTDRRFLPTK SKAFVALSSF
     PGAGNTWARH LIEHATGFYT GSYYFDGTLY NKGFKGEKDH WRSRRTICVK THESGKKEIE
     MFDSAILLIR NPYKSLVAEF NRKCAGHLGY ATDRNWKSKE WPEFVNSYAS WWASHVLDWL
     KYGKNLLVVH YEDLKQALIP KLKEMVEFMN ITVTEDRLLC VENNRDGNFK RSGPRPKAFE
     PFTTEMKDLI NKYIATVDKA LKARNFIGLP KEYLPR
//