ID H9G3P6_ANOCA Unreviewed; 576 AA.
AC H9G3P6;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=WSC domain-containing protein {ECO:0000259|PROSITE:PS51212};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000000393.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000000393.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000000393.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000000393.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at
CC the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
CC as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.
CC {ECO:0000256|ARBA:ARBA00035001}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the WSCD family.
CC {ECO:0000256|ARBA:ARBA00010236}.
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DR AlphaFoldDB; H9G3P6; -.
DR STRING; 28377.ENSACAP00000000393; -.
DR Ensembl; ENSACAT00000000410.4; ENSACAP00000000393.3; ENSACAG00000000404.4.
DR eggNOG; KOG4157; Eukaryota.
DR GeneTree; ENSGT00940000158096; -.
DR HOGENOM; CLU_029239_1_0_1; -.
DR InParanoid; H9G3P6; -.
DR TreeFam; TF324060; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000000404; Expressed in testis and 7 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR45964:SF5; WSC DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45964; WSCD FAMILY MEMBER CG9164; 1.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR Pfam; PF01822; WSC; 1.
DR SMART; SM00321; WSC; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51212; WSC; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 240..335
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
SQ SEQUENCE 576 AA; 66062 MW; 69D6F1E8D57F3537 CRC64;
MAKPFSRPQK FLWRTQFLLF FLTAAYLMAG SLLLLQRSRL VLQQGSRGTS GNQALPAAEM
FSPARDTETR PVQNPHLTPK LIVNMDMLHG PTPDQKYGPR WLISRNSELR QLRRRWFLRF
VNEQEPMQGA GAKVAKRAQE NKGTYIGCFD DDPREKMMKG AVFYDLRKMT IPHCQEACLN
CYSTTVFPCY NNRCAQSPVI CVSSCFCLVS GGSRCNHLYH TCSEACGGKS GGKWRWTGRH
AIYRGCFRAP ENLTNILPAV LIHLNLTVEM CSGFCSKKEF PLAVLRGSRC HCGFPTIHFP
LRNNSDKSLC IPSQNTSTVA ERSRGKDYWL VYQTPVQDTR CTDRRFLPTK SKAFVALSSF
PGAGNTWARH LIEHATGFYT GSYYFDGTLY NKGFKGEKDH WRSRRTICVK THESGKKEIE
MFDSAILLIR NPYKSLVAEF NRKCAGHLGY ATDRNWKSKE WPEFVNSYAS WWASHVLDWL
KYGKNLLVVH YEDLKQALIP KLKEMVEFMN ITVTEDRLLC VENNRDGNFK RSGPRPKAFE
PFTTEMKDLI NKYIATVDKA LKARNFIGLP KEYLPR
//