ID H9G465_ANOCA Unreviewed; 425 AA.
AC H9G465;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Abhydrolase domain containing 2, acylglycerol lipase {ECO:0000313|Ensembl:ENSACAP00000000679.2};
GN Name=ABHD2 {ECO:0000313|Ensembl:ENSACAP00000000679.2};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000000679.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000000679.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000000679.2};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000000679.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. AB hydrolase 4
CC family. {ECO:0000256|ARBA:ARBA00010884}.
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DR RefSeq; XP_008118378.1; XM_008120171.2.
DR AlphaFoldDB; H9G465; -.
DR STRING; 28377.ENSACAP00000000679; -.
DR MEROPS; S33.A56; -.
DR Ensembl; ENSACAT00000000701.4; ENSACAP00000000679.2; ENSACAG00000000736.4.
DR GeneID; 100553336; -.
DR KEGG; acs:100553336; -.
DR CTD; 11057; -.
DR eggNOG; KOG1838; Eukaryota.
DR GeneTree; ENSGT00950000182902; -.
DR HOGENOM; CLU_032487_5_0_1; -.
DR InParanoid; H9G465; -.
DR OMA; DHCRRFY; -.
DR OrthoDB; 4242155at2759; -.
DR TreeFam; TF313195; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000000736; Expressed in hemipenis and 13 other cell types or tissues.
DR GO; GO:0001669; C:acrosomal vesicle; IEA:Ensembl.
DR GO; GO:0036126; C:sperm flagellum; IBA:GO_Central.
DR GO; GO:0097524; C:sperm plasma membrane; IBA:GO_Central.
DR GO; GO:0008126; F:acetylesterase activity; IBA:GO_Central.
DR GO; GO:0047372; F:acylglycerol lipase activity; IBA:GO_Central.
DR GO; GO:0042562; F:hormone binding; IEA:Ensembl.
DR GO; GO:0033878; F:hormone-sensitive lipase activity; IEA:Ensembl.
DR GO; GO:0003707; F:nuclear steroid receptor activity; IEA:Ensembl.
DR GO; GO:0007340; P:acrosome reaction; IEA:Ensembl.
DR GO; GO:0046464; P:acylglycerol catabolic process; IBA:GO_Central.
DR GO; GO:0051792; P:medium-chain fatty acid biosynthetic process; IBA:GO_Central.
DR GO; GO:0051793; P:medium-chain fatty acid catabolic process; IBA:GO_Central.
DR GO; GO:0014912; P:negative regulation of smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:0032570; P:response to progesterone; IEA:Ensembl.
DR GO; GO:0009611; P:response to wounding; IEA:Ensembl.
DR GO; GO:0014909; P:smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:0048240; P:sperm capacitation; IBA:GO_Central.
DR GO; GO:0043401; P:steroid hormone mediated signaling pathway; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR000952; AB_hydrolase_4_CS.
DR InterPro; IPR012020; ABHD4.
DR PANTHER; PTHR10794; ABHYDROLASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10794:SF45; MONOACYLGLYCEROL LIPASE ABHD2; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PIRSF; PIRSF005211; Ab_hydro_YheT; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS01133; UPF0017; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Serine esterase {ECO:0000256|ARBA:ARBA00022487}.
FT DOMAIN 128..384
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
SQ SEQUENCE 425 AA; 48160 MW; 35195928D43E15B4 CRC64;
MSSLIMETPE LPAVFDGVKL AAVAAVLYII VRCLNLKSPT ASPDLIYQDT PLARFLLKSC
PLLTKEYIPP LIWGKSGHIQ TALYGKMGRV RSPHPYGLRK YITMPDGATA TFDLFEPLAE
HCIREDITMV ICPGIANHSE KQYIRTFVDY AQKNGYRCAV LNHLGALPNI ELTSPRMFTY
GCTWEFGSMV SYIRKTYPQT KLVVVGFSLG GNIVCKYLGE NQANQECVLC CVSVCQGYSA
LRAQETFMQW DQCRRLYNFL MADNMKKIIL SHRQTLFADG PKSPQNLIDS DLNRLHTATS
LMQIDDNIMR KFHGYNTLKE YYEQESCLHY LHRIYVPLLL VNAADDPLVH DSLLSIPRAL
SEKRENVMFV LPLHGGHLGF FEGAVLFPEP LTWMDKLVVQ YANAICQWEK NKSQCSDTEQ
SSGQE
//
