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Database: UniProt
Entry: H9G472_ANOCA
LinkDB: H9G472_ANOCA
Original site: H9G472_ANOCA 
ID   H9G472_ANOCA            Unreviewed;       860 AA.
AC   H9G472;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   25-OCT-2017, entry version 37.
DE   SubName: Full=Transient receptor potential cation channel subfamily C member 7 {ECO:0000313|Ensembl:ENSACAP00000000696};
GN   Name=TRPC7 {ECO:0000313|Ensembl:ENSACAP00000000696};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000000696, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000000696}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000000696};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Proteomes:UP000001646};
RX   PubMed=21881562; DOI=10.1038/nature10390;
RA   Alfoldi J., Di Palma F., Grabherr M., Williams C., Kong L.,
RA   Mauceli E., Russell P., Lowe C.B., Glor R.E., Jaffe J.D., Ray D.A.,
RA   Boissinot S., Shedlock A.M., Botka C., Castoe T.A., Colbourne J.K.,
RA   Fujita M.K., Moreno R.G., Ten Hallers B.F., Haussler D., Heger A.,
RA   Heiman D., Janes D.E., Johnson J., de Jong P.J., Koriabine M.Y.,
RA   Lara M., Novick P.A., Organ C.L., Peach S.E., Poe S., Pollock D.D.,
RA   de Queiroz K., Sanger T., Searle S., Smith J.D., Smith Z.,
RA   Swofford R., Turner-Maier J., Wade J., Young S., Zadissa A.,
RA   Edwards S.V., Glenn T.C., Schneider C.J., Losos J.B., Lander E.S.,
RA   Breen M., Ponting C.P., Lindblad-Toh K.;
RT   "The genome of the green anole lizard and a comparative analysis with
RT   birds and mammals.";
RL   Nature 477:587-591(2011).
RN   [3] {ECO:0000313|Ensembl:ENSACAP00000000696}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSACAP00000000696}.
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DR   STRING; 28377.ENSACAP00000000696; -.
DR   Ensembl; ENSACAT00000000719; ENSACAP00000000696; ENSACAG00000000336.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   InParanoid; H9G472; -.
DR   OMA; SEQCKQY; -.
DR   OrthoDB; EOG091G01FB; -.
DR   TreeFam; TF313147; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000000336; -.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   GO; GO:0007338; P:single fertilization; IBA:GO_Central.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005463; TRPC7_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF9; PTHR10117:SF9; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01648; TRPCHANNEL7.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|SAAS:SAAS00933366};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001646};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    351    371       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    383    403       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    472    493       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    578    601       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    649    671       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       50    127       ANK_REP_REGION. {ECO:0000259|Pfam:
FT                                PF12796}.
FT   DOMAIN      197    259       TRP_2. {ECO:0000259|Pfam:PF08344}.
FT   DOMAIN      392    682       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   860 AA;  99203 MW;  FA84A847EE01E398 CRC64;
     LENQSSVNMH RRHTTLREKG RRQATRGPAY MFNEKGTSLT AEEERFLDSA EYGNIPVVRK
     MLEESKTLNF NCVDYMGQNA LQLAVGNEHL EVTELLLKKE NLARVGDALL LAISKGYVRI
     VEAILNHPAF AQGQRLTLSP LEQELRDDDF YAYDEDGTRF SHDITPIILA AHCQEYEIVH
     ILLMKGARIE RPHDYFCKCN ECIEKQRKDS FSHSRSRMNA YKGLASAAYL SLSSEDPVLT
     ALELSNELAR LANIETEFKN DYRKLSMQCK DFVVGVLDLC RDTEEVEAIL NGDVTVQPWS
     ENHRPSLSRI KLAIKYEVKK FVAHPNCQQQ LLTMWYENLS GLRQQSMAVK FLAVFGVSIG
     LPFLAIAYWI APCSKLGRTL RSPFMKFVAH AVSFTIFLGL LVVNASDRFE GVKLLPNETA
     MDHPKQIFRV KTTQFSWTEM LIMKWVLGMI WSECKEIWEE GPREYVMHLW NLLDFGMLSI
     FVASFTARFM AFLKASEAQH YVDLYVQDED LNNVTLPPQV AYFTYARSRW LPSDPQIISE
     GLYAIAVVLS FSRIAYILPA NESFGPLQIS LGRTVKDIFK FMVIFIMVFL AFMIGMFNLY
     SYYLGAKYNP AFTTVEESFK TLFWSIFGLS EVISVVLKYD HKFIENIGYV LYGVYNVTMV
     VVLLNMLIAM INNSYQEIEE DADVEWKFAR AKLWLSYFDE GRTLPAPFNL VPSPKSFYYL
     IMRIKMCLIK LCKSKAKNCE NDLEMGMLNS KLRKVRFESS IQNSDFSVKN VYNKPTRYQK
     IMKRLIKRYV LKAQVDREND EVNEGELKEI KQDISSLRYE LLEEKSQATG ELASLIQQLS
     DKFGKSLNKD IFRVHSVKRI
//
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