ID   H9G6Q4_ANOCA            Unreviewed;      1311 AA.
AC   H9G6Q4;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   27-MAR-2024, entry version 63.
DE   SubName: Full=Tetratricopeptide repeat domain 21B {ECO:0000313|Ensembl:ENSACAP00000002727.3};
GN   Name=TTC21B {ECO:0000313|Ensembl:ENSACAP00000002727.3};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000002727.3, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000002727.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000002727.3};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000002727.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TTC21 family.
CC       {ECO:0000256|ARBA:ARBA00010935}.
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DR   STRING; 28377.ENSACAP00000002727; -.
DR   Ensembl; ENSACAT00000002795.3; ENSACAP00000002727.3; ENSACAG00000002696.3.
DR   eggNOG; ENOG502QQAB; Eukaryota.
DR   GeneTree; ENSGT00390000005979; -.
DR   HOGENOM; CLU_006149_0_0_1; -.
DR   InParanoid; H9G6Q4; -.
DR   TreeFam; TF314664; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000002696; Expressed in hindlimb bud and 13 other cell types or tissues.
DR   GO; GO:0005929; C:cilium; IEA:GOC.
DR   GO; GO:0030991; C:intraciliary transport particle A; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0060020; P:Bergmann glial cell differentiation; IEA:Ensembl.
DR   GO; GO:0021702; P:cerebellar Purkinje cell differentiation; IEA:Ensembl.
DR   GO; GO:0021798; P:forebrain dorsal/ventral pattern formation; IEA:Ensembl.
DR   GO; GO:0035721; P:intraciliary retrograde transport; IBA:GO_Central.
DR   GO; GO:1903999; P:negative regulation of eating behavior; IEA:Ensembl.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0061512; P:protein localization to cilium; IBA:GO_Central.
DR   GO; GO:0097499; P:protein localization to non-motile cilium; IEA:Ensembl.
DR   GO; GO:1905799; P:regulation of intraciliary retrograde transport; IEA:Ensembl.
DR   GO; GO:0008589; P:regulation of smoothened signaling pathway; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 5.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR040364; TTC21A/TTC21B.
DR   PANTHER; PTHR14699; STI2 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR14699:SF1; TETRATRICOPEPTIDE REPEAT PROTEIN 21B; 1.
DR   Pfam; PF13432; TPR_16; 1.
DR   Pfam; PF13181; TPR_8; 2.
DR   SMART; SM00028; TPR; 13.
DR   SUPFAM; SSF48452; TPR-like; 6.
DR   PROSITE; PS50005; TPR; 1.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        963..986
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REPEAT          722..755
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   1311 AA;  149010 MW;  85AABA88B8489A6A CRC64;
     RKPFHFQALI NYYCQEGYFH HVQTIASEGV KKFGNDPIFI FYRIYGTLME GHVQEALLDL
     ESIKNKPEVS LCTLMALIYA HKKSPNPDQE VISELDAKLK EQRKTAGQEA LYFAGLFLWH
     IGRHEKAREY IDRMIKISNG SKEGLILRGW IDVTSGKEAS IKKAAKYFDE GLQNGNDVFG
     LMGKAQYFEV RQNYSGALEN VNQIIANFPH FLPAFMKKMK LQLALQDWEQ ATETAHRLLQ
     KDALNLEAIK MEAIHHLCRE GNIREASSKL SDVISALDKL EPRNPQLFCK TALVFSRTCG
     RNPLILQQTQ TLVERAFSLA SHSADIATEL GYQMILQGKV KEASKWYGTA MALDETSVPA
     LTGIIRSQLM EGKLDDVEQQ LEFLNEIQQS IGKSAELSYL RAVLALKRHK RQEEVITLLN
     DVLDIHFSCL RGLPLGVEYF EKLNPDFLIE IIKEYLNFCP AQPAGPGQPP SPLLKPCASV
     LETLVKTVPG LQQAAYFTAK VKYLAGNSEA SQSILQHCIE QDPSYADAHL LMAQVHLSQN
     NFKLCSQSLE LCLSYNFEVR EHPVYHLIKA QAQIKMGEIT EAIKTLQMAM NLPGMRNTAS
     SSKSKSKKIE IDGSDRVSIY LELVEAHRLN GEQHEAIKVL QDAINEFSGT PEELRVVIAN
     ADLALAQEDV EGALTMLRNI TPEQTYYVQA KEKMAQVYLE YRKDKKLYAS CYRDLVEKMP
     SSHTFLLLGD AYMNIQEPEE ALEVYEQALK KNPRDGALAH KIGNALIKTH NYAKAISYYE
     AALKTGQHNF LSYDLAELLL KLNQYDKAEN VLQQVLDHES GILPQRLRGL LETTQEGVIC
     PRFTQRWEKE LLSARDLQAK VLKRIQIEQL DAVPMQKQLA AEICSEIAKH SATQRNYEKA
     IKFYKEALVY CETDNKVMLE LARLYLAYDD VDSCQRQCAL LLKNDPDNAA AAMWILTVNF
     NTVIFNSVLM FAYVYILNYV VILLIVSRFK SPSGEIKQGI NKHNKINNNA EIQAAGKDSS
     PPALDCLPRY TGEPNDALRH FNKARKDNDW GQNAVYNMIE ICLNPDNETM GGEVFEHLDT
     DTDTSSEKQE SVQLAVRTAE KLLKELKPQT VQGHVQLRIM ENYCLVATKQ KSNVERALNA
     FTEVVVNEKD HVPALLGMAI AYMILKQTPR ARNQLKRISK MNWNPIDAEE FEKSWLLLAD
     IYIQSSKYDM AGELLKRCLR NNRSCCKAYE YMGYIMEKEQ AYKDAAANYE MAWKYGNQTN
     PTIGFKLAFN YLKAKRYIDA INVCHKVLEA HPNYPKIRKE ILDKARASLR T
//