ID H9G6S5_ANOCA Unreviewed; 565 AA.
AC H9G6S5;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=WSC domain-containing protein {ECO:0000259|PROSITE:PS51212};
GN Name=wscd2 {ECO:0000313|Ensembl:ENSACAP00000002769.2};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000002769.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000002769.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000002769.2};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000002769.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at
CC the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
CC as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.
CC {ECO:0000256|ARBA:ARBA00035001}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}.
CC -!- SIMILARITY: Belongs to the WSCD family.
CC {ECO:0000256|ARBA:ARBA00010236}.
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DR RefSeq; XP_003225151.1; XM_003225103.3.
DR AlphaFoldDB; H9G6S5; -.
DR STRING; 28377.ENSACAP00000002769; -.
DR Ensembl; ENSACAT00000002839.4; ENSACAP00000002769.2; ENSACAG00000002830.4.
DR GeneID; 100553661; -.
DR KEGG; acs:100553661; -.
DR CTD; 9671; -.
DR eggNOG; KOG4157; Eukaryota.
DR GeneTree; ENSGT00940000159434; -.
DR HOGENOM; CLU_029239_0_0_1; -.
DR InParanoid; H9G6S5; -.
DR OMA; ERSNTCG; -.
DR OrthoDB; 3971278at2759; -.
DR TreeFam; TF324060; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000002830; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR45964:SF7; WSC DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45964; WSCD FAMILY MEMBER CG9164; 1.
DR Pfam; PF01822; WSC; 2.
DR SMART; SM00321; WSC; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51212; WSC; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 127..219
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT DOMAIN 230..324
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
SQ SEQUENCE 565 AA; 64728 MW; D8C6B856D2CC410C CRC64;
MAKLLLRFQR YFRRKPIRFF MLIALYLTAG SLVFLHASFT GQTRVPEHEP SPNSRAGDGT
EAKYLGTAQL GREVKNAPET LTTARRYGAW FKSPSKELPG RSKVGDYGGT WSRALKGRNV
REKEEDRAKY IGCYVDNTHR RALRGVSFFD YKKMTLFRCQ DNCAERGYLY AGLEFGAECY
CGHKIQAANV SNSECNMECK GEKSNICGGV NRLSIYRLEL AQESARRYGS AIFRGCFRRP
ENVSLALPAS RVMKNMSVDR CVDFCTSKEF PLAALAGESC HCGFPTTLFT LHEREDEQLC
AQKCSGEEFE SCGTAKYFIM YQTQVQDNRC MDRRFLTSRA KQFIALASFP GAGNTWARHL
IELATGYYTG SYYFDGSLYN KGFKGERDHW RSGRTICIKT HESGQKEIEA FDAAILLIRN
PYKALMAEFN RKYGGHIGFA SHAHWKGKEW PEFVRNYAPW WATHTLDWLK YGKRVLVVHF
EDLKHNLFIQ LKRMVGLLGI AVLEDRLLCV EGQKDGNFKR SGLRKLEYDP YTPEMRKTIN
GYIKTVDTAL KLRNLTGVPE DYYPR
//
