ID H9G744_ANOCA Unreviewed; 914 AA.
AC H9G744;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Rho GTPase activating protein 45 {ECO:0008006|Google:ProtNLM};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000003053.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000003053.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000003053.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000003053.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H9G744; -.
DR STRING; 28377.ENSACAP00000003053; -.
DR Ensembl; ENSACAT00000003131.4; ENSACAP00000003053.3; ENSACAG00000003070.4.
DR eggNOG; KOG1453; Eukaryota.
DR GeneTree; ENSGT00950000183110; -.
DR HOGENOM; CLU_006236_0_1_1; -.
DR InParanoid; H9G744; -.
DR TreeFam; TF351450; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000003070; Expressed in adrenal gland and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20816; C1_GMIP-like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF18; RHO GTPASE-ACTIVATING PROTEIN 45; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 201..477
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 563..608
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 622..833
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 914 AA; 102158 MW; 1B8BDEC42708FE50 CRC64;
MAKRPTSLSR HASAAGFPLS PAKGLPKSHK AHSPGDGVNA ESSLTDPEDI AQLLADVACF
AERLEKLKDV VLQEDGVESR RPVAHEYLGE ALRILRQIIS KYPLLNTLET LTAAGTLISK
VKGFHYESNN EAEKREFEKA VEMIAVSFSS TVSEFLMGEV DCSTILSMPP SDANQVSGAP
RFGPPQLNNN EPFLVFRLSA EEVDVLLQKC EGGVAFALKY AKNISKYMKD LIYYLEKRTA
LEMEFAKGLQ KMANTCKQTI TQEPHMPFLS IYSLALEQDS EYAASSLHAA VTLRMETFLQ
PLQTRRLEHE KRRKEIKEQW GRAQRKLQEA ENNLRKAKQV YMQRSEESEK AKNVAAKAEE
EQMGSVVGGG GGGGTGAVPN KALEKKRRLE EEARNKAEEA MATYRTCIAD ANTQRQELED
TKVTSLRQIH EVVKQSDQVI KSATISFYQT MHMQTAPLPV YFQTLCESSK LYDPGQQYAS
HVKRLQREDE PDTQYDFEPY VSHNWYGGRG HQVHKSWPTV IAETKDHPES NTSSSGIQEM
SPGVISAATG PFRHVGLSKA AQTHRLRKLR TPSKCRECNS YVYFQGAECE ECYLACHKKC
LETLAIQCGH KKLRGKLQLF GQDFLQASGS SSDGIPFIVQ KCILEIEKRA TRTKGIYRVN
GVKTRVEKLC QAFENGKELV ELSQASPHDI SNVLKLYLRQ LPEPILPFRM YNALMGLAKE
SLQGGKSAAE MADKGPETDP AVLALVTKLR ELLSKELPAE NRATLRFLVQ HLRRIVAAEG
ENKMTPGNLG IVFGPTLMRP RPTEATISLS SLVDYPHQAR IIEAFIIFYP DIFETVGDPQ
KQFLGSSDCG SGISFPADGS MGTQKASFPS PQWDYLFKYS ALASHILSPS SRMMRPHILC
RHRTRMRPHF TKVS
//
