ID H9G9M0_ANOCA Unreviewed; 806 AA.
AC H9G9M0;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Two pore segment channel 1 {ECO:0000313|Ensembl:ENSACAP00000004764.3};
GN Name=TPCN1 {ECO:0000313|Ensembl:ENSACAP00000004764.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000004764.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000004764.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000004764.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000004764.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003226073.1; XM_003226025.3.
DR AlphaFoldDB; H9G9M0; -.
DR STRING; 28377.ENSACAP00000004764; -.
DR Ensembl; ENSACAT00000004872.4; ENSACAP00000004764.3; ENSACAG00000004804.4.
DR GeneID; 100560676; -.
DR KEGG; acs:100560676; -.
DR CTD; 53373; -.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000158958; -.
DR HOGENOM; CLU_019500_0_0_1; -.
DR InParanoid; H9G9M0; -.
DR OrthoDB; 5403296at2759; -.
DR TreeFam; TF328550; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000004804; Expressed in embryonic post-anal tail and 13 other cell types or tissues.
DR GO; GO:0031901; C:early endosome membrane; IEA:Ensembl.
DR GO; GO:0036019; C:endolysosome; IEA:Ensembl.
DR GO; GO:0010008; C:endosome membrane; IBA:GO_Central.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:Ensembl.
DR GO; GO:0097682; F:intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity; IEA:Ensembl.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:Ensembl.
DR GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IEA:Ensembl.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0019905; F:syntaxin binding; IEA:Ensembl.
DR GO; GO:0022832; F:voltage-gated channel activity; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:Ensembl.
DR GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028801; TPC1_animal.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46474; TWO PORE CALCIUM CHANNEL PROTEIN 1; 1.
DR PANTHER; PTHR46474:SF1; TWO PORE CHANNEL PROTEIN 1; 1.
DR Pfam; PF00520; Ion_trans; 2.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 97..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 466..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 556..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..320
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 431..680
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 782..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 93784 MW; 576A4C121EA653A0 CRC64;
MAASPEDDDV PLILTLEESR SPAALRENGG NYDLVNDTHS PAAGDCYPQP TCGRHNWEMN
YQESAIYLQE GANNDKFLTH PKDAKALAAY LFVHNHLFYL MELSTALLLL LLSLCEAPAV
PMLRLGIYIH ATLELLALTV VVFELSMKMR WLGFHTYIRH KRTMVKTSVL LLQFVEAIVV
LVRQTSHVRI TRALRCIFLV DCRYCGAVRR NLRQIFQSLP PFIDILLLLL FFMVIFAILG
FYLFSPNKSD PYFNTLENSL VNLFVLLTTA NFPDVMMPSY ARSPWSCVFF IVYLSIELYF
IMNLLLAVVF DTFNDIEKRK FRSLLLHKRT AIQHAYRLLV SKQRPAGIPF KQFDGLMRFY
KPRMSARDRY LTFKALNQSN THLLSLKDMY SFYEVVGLKW KAKRNREHWF DDLPRTAFLI
FKGINILVNS RAFQYTMYTL VAVNGLWILV ETFMLRDGIF SRDVPWSYIV FLTIYGVEVL
LKITGLGPVE YLSSGWNLFD FSVTLFAFLG LLALAFDMEP FYFIVVLRPL QLLRLFKLKK
RYRNVLDTMF ELLPRMASLG LTLLIFYYCF AIIGMEFFSG KVFPNCCNAS TVADAYRWVN
HTIGNKTVME EGYYYLNNFD NVLNSFVTLF ELTVVNDWYI IMEGVTSETS HWSRLYFMIF
YIVTMVVMTI IVAFILEAFV FRMNYTRKNH DSEEDSGIVL EREVSKEEVT AVAEMYGRFS
SASAAGQLLR IVSQMDRHQQ TSMLFLGRRS RTKSDLSMKM YEEEIQEWYE EHARKEERHF
PWQGDGEMLS PPLTAPGLRQ RSQTII
//
