ID H9GA93_ANOCA Unreviewed; 753 AA.
AC H9GA93;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 24-JAN-2024, entry version 59.
DE SubName: Full=Premelanosome protein {ECO:0000313|Ensembl:ENSACAP00000005360.3};
GN Name=PMEL {ECO:0000313|Ensembl:ENSACAP00000005360.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000005360.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000005360.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000005360.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000005360.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PMEL/NMB family.
CC {ECO:0000256|ARBA:ARBA00025776}.
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DR RefSeq; XP_008112630.1; XM_008114423.2.
DR AlphaFoldDB; H9GA93; -.
DR STRING; 28377.ENSACAP00000005360; -.
DR Ensembl; ENSACAT00000005477.4; ENSACAP00000005360.3; ENSACAG00000005471.4.
DR GeneID; 100555348; -.
DR KEGG; acs:100555348; -.
DR CTD; 6490; -.
DR eggNOG; ENOG502QV5K; Eukaryota.
DR GeneTree; ENSGT00950000183188; -.
DR HOGENOM; CLU_017264_0_0_1; -.
DR InParanoid; H9GA93; -.
DR OrthoDB; 5354575at2759; -.
DR TreeFam; TF334865; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000005471; Expressed in kidney and 7 other cell types or tissues.
DR GO; GO:0033106; C:cis-Golgi network membrane; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0042470; C:melanosome; IBA:GO_Central.
DR GO; GO:0033162; C:melanosome membrane; IEA:Ensembl.
DR GO; GO:0032585; C:multivesicular body membrane; IEA:Ensembl.
DR GO; GO:0097487; C:multivesicular body, internal vesicle; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0042438; P:melanin biosynthetic process; IEA:Ensembl.
DR GO; GO:0032438; P:melanosome organization; IBA:GO_Central.
DR GO; GO:0048023; P:positive regulation of melanin biosynthetic process; IEA:Ensembl.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR045219; PKAT.
DR InterPro; IPR046846; PKAT_KLD.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR11861:SF1; MELANOCYTE PROTEIN PMEL; 1.
DR PANTHER; PTHR11861; MELANOCYTE PROTEIN PMEL 17-RELATED; 1.
DR Pfam; PF20433; PKAT_KLD; 1.
DR Pfam; PF00801; PKD; 1.
DR SMART; SM00089; PKD; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..753
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003620996"
FT TRANSMEM 680..700
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 261..298
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 334..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..385
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 753 AA; 78671 MW; 71808D5E0618EE59 CRC64;
MLQSRWYLWV ALGALLAVAT AQRRAYGRNN KREQNWSQKH PGYKTWNSRL YPKWREGDAK
QRNCWKGGEV TFDISNDAPT ITGAKATFSI ALRFPGNQTV LPDGRVVWSH NCTVNGTYVS
EGDPVFPDQG TNASDCFFPD GQPFSPSDRG KRGKFVYVWQ TWGRYWQVVD GPASLLTIDT
GEVPLGSYSM EVEVYHYRGR EKFIPIGGTS SQFSITDQIP FNVDIAQVLD VDGADGSFVL
NRAISFGVRL HDPSQYLRDA DISYSWDFGD GSGTLISQAT MVTHTYLTVG TFSPRVVLQA
AIPLGSCGST SEEPLIIPTT ALGSTVAQAT IPVTTPSPTT AQSPTALPTV SSIPGTGSAG
VQSPVPDPVT PAVPSEQPPE PATPEADPLS TAAAAAAVTV ISAVPEGAGL AVASVDPATV
VSANVVDDTA GTEDPLAMTT AMPASLPGTI APTAAATAVP ASLPGTEQPA SSITATVEDA
PDTLASTVLS PAASTAVLPG ASTTLPSATN TPVSPVAGST EDAATISLPV SVPTETGTIA
TEVVQIVVKR QAPSSCLLYR YGTFGTNLDI VQGIESVEIV QIVPLVTAVA DNTVDLTVTC
QGSLPDEVCT TISDPECLVA QETVCSPVQP SPDCQLVLRQ AFNDSGVYCV NISLANANSL
AVASTQVNIQ AGRSPASSQI TLVVGVVLVA AALGAVAYVY RRARYIPLRA VMSAGTSPRS
WLPDRTAVRL FLRQAFGQGA NGESSPLLSG NVI
//