ID H9GAN5_ANOCA Unreviewed; 718 AA.
AC H9GAN5;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Hook microtubule tethering protein 3 {ECO:0000313|Ensembl:ENSACAP00000005752.3};
GN Name=HOOK3 {ECO:0000313|Ensembl:ENSACAP00000005752.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000005752.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000005752.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000005752.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000005752.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the hook family.
CC {ECO:0000256|ARBA:ARBA00006946}.
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DR RefSeq; XP_003226077.1; XM_003226029.3.
DR AlphaFoldDB; H9GAN5; -.
DR STRING; 28377.ENSACAP00000005752; -.
DR Ensembl; ENSACAT00000005879.4; ENSACAP00000005752.3; ENSACAG00000005732.4.
DR GeneID; 100561464; -.
DR KEGG; acs:100561464; -.
DR CTD; 84376; -.
DR eggNOG; ENOG502QQM8; Eukaryota.
DR GeneTree; ENSGT00940000158075; -.
DR HOGENOM; CLU_011214_1_0_1; -.
DR InParanoid; H9GAN5; -.
DR OrthoDB; 50921at2759; -.
DR TreeFam; TF320231; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000005732; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0005801; C:cis-Golgi network; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0070695; C:FHF complex; IEA:Ensembl.
DR GO; GO:0030897; C:HOPS complex; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0000242; C:pericentriolar material; IEA:Ensembl.
DR GO; GO:0034452; F:dynactin binding; IEA:Ensembl.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:Ensembl.
DR GO; GO:0045503; F:dynein light chain binding; IEA:Ensembl.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IBA:GO_Central.
DR GO; GO:0045022; P:early endosome to late endosome transport; IEA:Ensembl.
DR GO; GO:0007032; P:endosome organization; IEA:Ensembl.
DR GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0051645; P:Golgi localization; IEA:Ensembl.
DR GO; GO:0022027; P:interkinetic nuclear migration; IEA:Ensembl.
DR GO; GO:0007040; P:lysosome organization; IEA:Ensembl.
DR GO; GO:0034454; P:microtubule anchoring at centrosome; IEA:Ensembl.
DR GO; GO:0050768; P:negative regulation of neurogenesis; IEA:Ensembl.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0071539; P:protein localization to centrosome; IEA:Ensembl.
DR GO; GO:1905719; P:protein localization to perinuclear region of cytoplasm; IEA:Ensembl.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR008636; Hook_C.
DR InterPro; IPR043936; HOOK_N.
DR PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR PANTHER; PTHR18947:SF38; PROTEIN HOOK HOMOLOG 3; 1.
DR Pfam; PF05622; HOOK; 1.
DR Pfam; PF19047; HOOK_N; 1.
DR SUPFAM; SSF116907; Hook domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 10..126
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 682..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 171..430
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 489..657
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 686..709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 718 AA; 83225 MW; EA10BAD67D6CCFAF CRC64;
MFNVESLERA ELGESLLTWI QTFNIEAPCQ TVEDLTSGVV MAQVLQKIDP SYFDENWLNR
IKTEVGDNWR LKVSNLKKIL KGILDYNHEI LGQQINDFIL PDVNLIGEHS DAAELGRMLQ
LILGCAVNCE QKQEYIQTIM MMEESVQHVV MTAIQELMSK ESPVTAGNDA YVDLDRQLKK
TTEELNEALS TKEEIAQRCH ELDMQVAALQ EEKSSLLAEN QVLMERLNQS DSIEDPNSPA
GRRHLQLQSQ LEQLQEETFR LEAAKDDYRI RCEELEKEIV ELRQQNEELT NLAEEAQSLK
DEMDVLRHSS DKVAKLESQV DSYKKKLEDL GDLRRQVKLL EEKNTMYMQN TVSLEEELRK
ANAARSQLET YKRQVVELQN RLSEESKKAD KLEFEYKMLK EKVDSLQKEK DRLRTERDSL
KETIEEIRCV QAQEGQLTTS GLLPLAGQES SDSLAAEIIT PEIREKLLRL QHENKILKLN
QEGSDNEKIA LLQSLLDDAN LRKNELETEN RLVNQRLLEV QSQVEELQKS LQEQGSKAED
SVILKKKLDE HLEKLHEANN ELQKKRAIIE DLEPRYNNSS LKIEELQEAL RKKEEEMKQM
EERYKKYLEK AKSVIRTLDP KQNQGSAPEI QALKNQLQER ERMFHSLEKE YEKTKSQREM
EEKYIVSAWY NMGMTLHKKA AEDRLASTGS GQSFLARQRQ ATSTRRAYPG HVQPATAR
//
