ID H9GC71_ANOCA Unreviewed; 696 AA.
AC H9GC71;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=TGF-beta activated kinase 1 (MAP3K7) binding protein 2 {ECO:0000313|Ensembl:ENSACAP00000006862.2};
GN Name=TAB2 {ECO:0000313|Ensembl:ENSACAP00000006862.2};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000006862.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000006862.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000006862.2};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000006862.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016851363.1; XM_016995874.1.
DR AlphaFoldDB; H9GC71; -.
DR STRING; 28377.ENSACAP00000006862; -.
DR Ensembl; ENSACAT00000007012.4; ENSACAP00000006862.2; ENSACAG00000006999.4.
DR GeneID; 100553005; -.
DR KEGG; acs:100553005; -.
DR CTD; 23118; -.
DR eggNOG; ENOG502QRAY; Eukaryota.
DR GeneTree; ENSGT00940000158473; -.
DR HOGENOM; CLU_025065_0_0_1; -.
DR InParanoid; H9GC71; -.
DR OMA; GPTFIHH; -.
DR OrthoDB; 5400650at2759; -.
DR TreeFam; TF332021; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000006999; Expressed in embryonic post-anal tail and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0070530; F:K63-linked polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0038061; P:non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR CDD; cd14362; CUE_TAB2_TAB3; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR003892; CUE.
DR InterPro; IPR041911; TAB2/3_CUE.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR46253:SF2; TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 2; 1.
DR PANTHER; PTHR46253; TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN TAB; 1.
DR Pfam; PF02845; CUE; 1.
DR SMART; SM00546; CUE; 1.
DR SMART; SM00547; ZnF_RBZ; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR PROSITE; PS51140; CUE; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT DOMAIN 8..51
FT /note="CUE"
FT /evidence="ECO:0000259|PROSITE:PS51140"
FT DOMAIN 666..696
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT REGION 198..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 538..620
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 209..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 696 AA; 76613 MW; 1B2A3DE1F9EAA051 CRC64;
MAQGSQQIDF QVLHDLRQKF PEVPEVVVSR CMLQNNNNLD ACCAVLSKES TKYLYGEGDI
GFSDDSGISS LRNHMTSLNL DLQSQNVILH GREGSRMNGS RTLAHSISDG HLQTSQSNSE
LFHHEPQTAP VQVPQGFFGI SNTVSTSNPG PHFGFHLGSK GTPGLVQQTP RFNPIMVTLA
PNIQPGRNTP TSLHIHGVPP LNHPQGNSIY IRPYITNPSG TTRQSNQNPG WTSQFNPLHS
QQNFQPSHPN PWTAVPTTSS SSHTSSQQAS QPNQQGHQTS HVYMPISSPT TPQAPTVHSS
GSSQSSSAQS QYNIQNISTG PRKNQIEIKL EPPQRNSSSK LRSTGPRSSS NSSSNNSQTL
SRSQPTVYIA ASPPNTDEVI TRSQPKVYIS ANASTGDEQH VRNQPTLFIS TNPGVTATSR
NMSGQVSMGP AFIHHHPPKS RAVGNNATAT SPRVVVTQPN TKYTFKITVS PNKPPAVSPG
VVSPTFEPTN LLNLPDHFAE TEGIQHLTDP VLAHVDRISE VRKLSMGSDD AAYTQALLVH
QKARMERLQR ELEIQKKKLD KLKTEVNEME NNLTRRRLKR SNSASQIPSL EEMQQLRSCN
RQLQIDIDCL TKEIDLFQAR GPHFNPSAIH NFYDNIGFLG PVPPKPKADQ RSSIKTPKTV
PDTEEDEGAQ WNCTACTFLN HPALNRCEQC EMPRHF
//
