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Database: UniProt
Entry: H9GD25_ANOCA
LinkDB: H9GD25_ANOCA
Original site: H9GD25_ANOCA 
ID   H9GD25_ANOCA            Unreviewed;      1426 AA.
AC   H9GD25;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   24-JAN-2024, entry version 75.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   Name=YTHDC2 {ECO:0000313|Ensembl:ENSACAP00000007635.3};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000007635.3, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000007635.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000007635.3};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000007635.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR   STRING; 28377.ENSACAP00000007635; -.
DR   Ensembl; ENSACAT00000007798.3; ENSACAP00000007635.3; ENSACAG00000007754.3.
DR   eggNOG; KOG0920; Eukaryota.
DR   eggNOG; KOG0922; Eukaryota.
DR   eggNOG; KOG1902; Eukaryota.
DR   GeneTree; ENSGT00940000155826; -.
DR   HOGENOM; CLU_001832_1_6_1; -.
DR   InParanoid; H9GD25; -.
DR   TreeFam; TF318311; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000007754; Expressed in embryonic post-anal tail and 13 other cell types or tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0035770; C:ribonucleoprotein granule; IEA:Ensembl.
DR   GO; GO:0034458; F:3'-5' RNA helicase activity; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IBA:GO_Central.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:1990247; F:N6-methyladenosine-containing RNA reader activity; IEA:Ensembl.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0070063; F:RNA polymerase binding; IEA:Ensembl.
DR   GO; GO:0051729; P:germline cell cycle switching, mitotic to meiotic cell cycle; IEA:Ensembl.
DR   GO; GO:0048599; P:oocyte development; IEA:Ensembl.
DR   GO; GO:0044829; P:positive regulation by host of viral genome replication; IEA:Ensembl.
DR   GO; GO:0070555; P:response to interleukin-1; IEA:Ensembl.
DR   GO; GO:0034612; P:response to tumor necrosis factor; IEA:Ensembl.
DR   GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR   CDD; cd17987; DEXHc_YTHDC2; 1.
DR   CDD; cd06007; R3H_DEXH_helicase; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   CDD; cd21134; YTH; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR   Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR034083; R3H_DEXH_helicase.
DR   InterPro; IPR001374; R3H_dom.
DR   InterPro; IPR036867; R3H_dom_sf.
DR   InterPro; IPR007275; YTH_domain.
DR   PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   Pfam; PF01424; R3H; 1.
DR   Pfam; PF04146; YTH; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00393; R3H; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   SUPFAM; SSF82708; R3H domain; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51061; R3H; 1.
DR   PROSITE; PS50882; YTH; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT   DOMAIN          42..110
FT                   /note="R3H"
FT                   /evidence="ECO:0000259|PROSITE:PS51061"
FT   DOMAIN          207..373
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          615..782
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   DOMAIN          1284..1414
FT                   /note="YTH"
FT                   /evidence="ECO:0000259|PROSITE:PS50882"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1157..1195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1220..1284
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1178..1192
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1222..1238
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1239..1259
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1426 AA;  160095 MW;  593B0B04051D204F CRC64;
     MSRPSSVSPR PPALSGPSIS MAASTSSASS RGGGGRSKGL KDIRIDEEVK IAVNIALERF
     RYGDQREMEF PSSFTSTERA FIHRLSQSLG LISKSKGKGA NRYLTVKKKD GSELAHAVMT
     CNLIPNTKHA IRSLVQRFPV TNKERTELLP KTERGNVFAV EAENREMSKT SGRLNNGIPQ
     IPVKRGESEF DSFRQSLPVY EKQDEIVRII KENKVVLIVG ETGSGKTTQI PQFLLDDSYK
     NGIPCRIFCT QPRRLAAIAV AERVAAERRE KIGQTIGYQI RLESRVSPKT LLTFCTNGVL
     LRTLMAGDSA LSTVTHVIVD EVHERDRFSD FLLTKLRDTL QKHSSLKLIL SSAALDVNLF
     VRYFGGCPVI YIPGRPFEVK EMFLEDLLRT TGYTNKEMIK YKKEKQREEK QQTTLTEWYS
     AQDNSKPELQ RQRAVLNVAE EYDLLDDGGD TVFSQLAEKD VNCLEPWLIK EMDACLSDIW
     LHKDIDAFAQ VFHLILTENV SVDYRHSETS ATTLMVASGR GFLSQVEQLI GMGANVHIKS
     SNGWTALEWA KHFGQTEVVD LLESYCASLE SGNLDESSLV HANASELSVE DQELLKAYHH
     SFDDEKVDLD LIMHLLYNIC HSCEAGAVLI FLPGYDEIVG LRDRILFDDK RFADNAHRFQ
     VFMLHSNMQT SDQKKVLKTS PPGIRKIILS TNIAETSITV NDVVFVIDSG KMKEKSFDAL
     NCVTMLKMVW ISKASAIQRK GRAGRCRPGI CFRLFSRLRF QNMLEFQTPE LLRMPLQVSS
     LSLFHRNLHK NGSALLYYQL ECTIDAMDTW EDLTELGYHL ADLPVEPHLG KMVLCAVVLK
     CLDPILTIAC TLAYRDPFVL PTQASQKRAA MLCRKRFTAG TFSDHMALLR AFQAWQKARS
     DGWERAFCEK NFLSQATMEI IIGMRTQLLG QLRASGFVRA RGGGDIRDVN TNSENWAVVK
     GALVAGMYPN IVHVDRENTV LTGPKEKKVR FHPTSVLSQP QYKKIPPANG QVAAIQALPT
     DWLIYDEMTR AHRIANIRCC SVVTPVTVAL FCGSARLPSN ASEVELSIFL IVDGAPNDSS
     DSEMEDRTTA NLAALKLDEW LNFKLDPEAA SLLLQLRQKW HSLFLRRMRA PSKPWSQVDE
     ATIRAIIAVL STEEQSAGLQ QPSGIGQRPR PMSSEELPLA SSWRSNTSRK TSAEAEFADE
     AFNSERVLMK SASPAFHQPL KYKERSVLHP KRSTEDRSDQ QISQISSSVK STDSSSYPSP
     CASPSPPSSG KGSKSPSPRP NMPVRYFIMK SSNLRNLEIS QQKGIWSTTP SNERKLNRAF
     WESSVVYLVF SVQGSGHFQG FARMSSEIGR EKSQDWGSTG LGGVFKVEWI RKESLPFQFA
     HHLLNPWNDN KKVQISRDGQ ELEPQVGEQL LQLWDRIPLG ERNMAD
//
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