ID H9GD25_ANOCA Unreviewed; 1426 AA.
AC H9GD25;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 24-JAN-2024, entry version 75.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=YTHDC2 {ECO:0000313|Ensembl:ENSACAP00000007635.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000007635.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000007635.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000007635.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000007635.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR STRING; 28377.ENSACAP00000007635; -.
DR Ensembl; ENSACAT00000007798.3; ENSACAP00000007635.3; ENSACAG00000007754.3.
DR eggNOG; KOG0920; Eukaryota.
DR eggNOG; KOG0922; Eukaryota.
DR eggNOG; KOG1902; Eukaryota.
DR GeneTree; ENSGT00940000155826; -.
DR HOGENOM; CLU_001832_1_6_1; -.
DR InParanoid; H9GD25; -.
DR TreeFam; TF318311; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000007754; Expressed in embryonic post-anal tail and 13 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0035770; C:ribonucleoprotein granule; IEA:Ensembl.
DR GO; GO:0034458; F:3'-5' RNA helicase activity; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:1990247; F:N6-methyladenosine-containing RNA reader activity; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0070063; F:RNA polymerase binding; IEA:Ensembl.
DR GO; GO:0051729; P:germline cell cycle switching, mitotic to meiotic cell cycle; IEA:Ensembl.
DR GO; GO:0048599; P:oocyte development; IEA:Ensembl.
DR GO; GO:0044829; P:positive regulation by host of viral genome replication; IEA:Ensembl.
DR GO; GO:0070555; P:response to interleukin-1; IEA:Ensembl.
DR GO; GO:0034612; P:response to tumor necrosis factor; IEA:Ensembl.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR CDD; cd17987; DEXHc_YTHDC2; 1.
DR CDD; cd06007; R3H_DEXH_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR CDD; cd21134; YTH; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.10.590.10; ph1033 like domains; 1.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR034083; R3H_DEXH_helicase.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR007275; YTH_domain.
DR PANTHER; PTHR18934:SF213; 3'-5' RNA HELICASE YTHDC2; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF04146; YTH; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS50882; YTH; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 42..110
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 207..373
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 615..782
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1284..1414
FT /note="YTH"
FT /evidence="ECO:0000259|PROSITE:PS50882"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1157..1195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1220..1284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1178..1192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1222..1238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1239..1259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1426 AA; 160095 MW; 593B0B04051D204F CRC64;
MSRPSSVSPR PPALSGPSIS MAASTSSASS RGGGGRSKGL KDIRIDEEVK IAVNIALERF
RYGDQREMEF PSSFTSTERA FIHRLSQSLG LISKSKGKGA NRYLTVKKKD GSELAHAVMT
CNLIPNTKHA IRSLVQRFPV TNKERTELLP KTERGNVFAV EAENREMSKT SGRLNNGIPQ
IPVKRGESEF DSFRQSLPVY EKQDEIVRII KENKVVLIVG ETGSGKTTQI PQFLLDDSYK
NGIPCRIFCT QPRRLAAIAV AERVAAERRE KIGQTIGYQI RLESRVSPKT LLTFCTNGVL
LRTLMAGDSA LSTVTHVIVD EVHERDRFSD FLLTKLRDTL QKHSSLKLIL SSAALDVNLF
VRYFGGCPVI YIPGRPFEVK EMFLEDLLRT TGYTNKEMIK YKKEKQREEK QQTTLTEWYS
AQDNSKPELQ RQRAVLNVAE EYDLLDDGGD TVFSQLAEKD VNCLEPWLIK EMDACLSDIW
LHKDIDAFAQ VFHLILTENV SVDYRHSETS ATTLMVASGR GFLSQVEQLI GMGANVHIKS
SNGWTALEWA KHFGQTEVVD LLESYCASLE SGNLDESSLV HANASELSVE DQELLKAYHH
SFDDEKVDLD LIMHLLYNIC HSCEAGAVLI FLPGYDEIVG LRDRILFDDK RFADNAHRFQ
VFMLHSNMQT SDQKKVLKTS PPGIRKIILS TNIAETSITV NDVVFVIDSG KMKEKSFDAL
NCVTMLKMVW ISKASAIQRK GRAGRCRPGI CFRLFSRLRF QNMLEFQTPE LLRMPLQVSS
LSLFHRNLHK NGSALLYYQL ECTIDAMDTW EDLTELGYHL ADLPVEPHLG KMVLCAVVLK
CLDPILTIAC TLAYRDPFVL PTQASQKRAA MLCRKRFTAG TFSDHMALLR AFQAWQKARS
DGWERAFCEK NFLSQATMEI IIGMRTQLLG QLRASGFVRA RGGGDIRDVN TNSENWAVVK
GALVAGMYPN IVHVDRENTV LTGPKEKKVR FHPTSVLSQP QYKKIPPANG QVAAIQALPT
DWLIYDEMTR AHRIANIRCC SVVTPVTVAL FCGSARLPSN ASEVELSIFL IVDGAPNDSS
DSEMEDRTTA NLAALKLDEW LNFKLDPEAA SLLLQLRQKW HSLFLRRMRA PSKPWSQVDE
ATIRAIIAVL STEEQSAGLQ QPSGIGQRPR PMSSEELPLA SSWRSNTSRK TSAEAEFADE
AFNSERVLMK SASPAFHQPL KYKERSVLHP KRSTEDRSDQ QISQISSSVK STDSSSYPSP
CASPSPPSSG KGSKSPSPRP NMPVRYFIMK SSNLRNLEIS QQKGIWSTTP SNERKLNRAF
WESSVVYLVF SVQGSGHFQG FARMSSEIGR EKSQDWGSTG LGGVFKVEWI RKESLPFQFA
HHLLNPWNDN KKVQISRDGQ ELEPQVGEQL LQLWDRIPLG ERNMAD
//