ID H9GIA1_ANOCA Unreviewed; 600 AA.
AC H9GIA1;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000011691.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000011691.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000011691.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000011691.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GAB family. {ECO:0000256|ARBA:ARBA00029462}.
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DR AlphaFoldDB; H9GIA1; -.
DR STRING; 28377.ENSACAP00000011691; -.
DR Ensembl; ENSACAT00000011932.3; ENSACAP00000011691.3; ENSACAG00000011922.3.
DR eggNOG; ENOG502QU11; Eukaryota.
DR GeneTree; ENSGT00940000159803; -.
DR HOGENOM; CLU_028652_1_0_1; -.
DR InParanoid; H9GIA1; -.
DR TreeFam; TF329487; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000011922; Expressed in heart and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0035591; F:signaling adaptor activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046355; Gab1-4-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45960; GRB2-ASSOCIATED-BINDING PROTEIN; 1.
DR PANTHER; PTHR45960:SF3; GRB2-ASSOCIATED-BINDING PROTEIN 3; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 15..119
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 128..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..466
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 600 AA; 66971 MW; C6BE2DF9D1DE3ADF CRC64;
MSCIWYKFPS FCSPSVMPSP LLFFPQAWRK RWFVLRQGRM SGNPDVLEYY RNSHSKKPIR
VIDLNECEVV KHSGLNFIKK EFQNNFVFVV KTAYRTFYLV AKSEEEMQAW VHHITQICNF
GHLEDGTDSG DSLSHTTSSP QPSPATSAHA LRTAETSSSV DQPTSDASAA EETASESESV
FLPDYLFLSN CETGKLSHVR CHSWSNSDRS LEQTSSDDVF VDFVASQPSL FLQSSGGPLQ
EILSPTCQGL LPRNPDSSGP PSSDFSSSSP LSGPPLTPTF LVDKSQNTLS LGVVELDVLA
NTPPPRPPKP THLSDRRAEE QPFGGLQNGH SGISSSQRVV VPRRISMSGL DSMRNWRVDM
DESSLRSRDK RLSLNLPCRF SPLYSSTSNS SEDSYVPMHP SASPPLPGSD CTPDGYIPMS
PGSTAFAVST VNTEKLPSPL PELPTDLEPP PVNRDLKPRR KFRPPPLDLR NLSTIREHAA
LTRTWTVPYN RTSFISPERD CIYSAKVFAS SISGEEEESY IQMEHQQATS PYNGALFQWP
KKFNVDYLAL DFNSASPSPV QKKPFLSEEQ RVDYVQVDEQ RTQALQSTKQ EWTDERQSKV
//
