ID H9GJD5_ANOCA Unreviewed; 1242 AA.
AC H9GJD5;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=RAS protein activator like 2 {ECO:0000313|Ensembl:ENSACAP00000012641.3};
GN Name=RASAL2 {ECO:0000313|Ensembl:ENSACAP00000012641.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000012641.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000012641.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000012641.3};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000012641.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008116004.1; XM_008117797.2.
DR AlphaFoldDB; H9GJD5; -.
DR STRING; 28377.ENSACAP00000012641; -.
DR Ensembl; ENSACAT00000012897.4; ENSACAP00000012641.3; ENSACAG00000012811.4.
DR GeneID; 100558167; -.
DR CTD; 9462; -.
DR eggNOG; KOG3508; Eukaryota.
DR GeneTree; ENSGT00940000157702; -.
DR HOGENOM; CLU_001727_1_0_1; -.
DR OrthoDB; 22721at2759; -.
DR TreeFam; TF105303; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000012811; Expressed in forelimb bud and 13 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd04013; C2_SynGAP_like; 1.
DR CDD; cd05136; RasGAP_DAB2IP; 1.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR021887; DAB2P_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF52; RAS GTPASE-ACTIVATING PROTEIN NGAP; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12004; DAB2P_C; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 44..294
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 285..403
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 463..655
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 123..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1100..1173
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 150..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1009..1074
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1242 AA; 139867 MW; BD9029ADDC3963FD CRC64;
MEGGPSAGEA SLETGLERLR NSLPGPADLA AAAGTLERIL RESVCQLQGW LRVYDVTGPP
THRLSCGQSP DSETVIWDTK YTILTDSQLV MLNKEKEMAV EGGQEQTTEP PTKGRCLRRT
VSVPSEGQFP DYPPEGAAKL EVPAERSPRR RSISGTSTSD KTNPMDASNT SPFKVPGFFS
KRLKGSIKRT KSQSKLDRNT SFRLPSLQPA DDRSRGLPKL KESRSHESLL SPASAVETLD
LATEDRVHVK SLHGSILGKD FCFEVTYSSG SKCFSCSSAA ERDKWMENLR RAIQPNKDNC
RRAENVLRLW IIEAKDLTPK KKYFCELCLD DTLFARTTSK TKADNIFWGE HFEFYSLPSI
HSITVHIYKD VEKKKKKDKN NYVGLVNIPI ASVTGRQFVE KWYPISTPTP NKGKAGGPSI
RIKSRYQTIT ILPMEQYKEF AEFITNNYAV LCSVLEPVIS VRNKEEMACA LVHILQSTGR
AKDFLTDLVM SEVDRCGEHD VLIFRENTLA TKAIEEYLKL VGQKYLQDAL GEFIKALYES
DENCEVDPSK CSSSEVHEHQ ANLKMCCELA FCKIINSYCV FPRELKEVFA SWKQQFLNRG
KQDISERLIS ASLFLRFLCP AIMSPSLFNL MQEYPDDRTS RTLTLIAKVI QNLANFTRFG
NKEEYITFMN DFLEHEWGSM KRFLVEISNA DTISNTPGFE GYIDLGREIA ILHSLLWEVV
CQLDKGENSF LQATVEKLGP LPRILTDIAK ATTNPTPIQQ QLRRLADHNS SPNVSLSSGL
QKIFEDPTDS EIKCKSPPEE NEGYFKGNLL LIQQSSSRSV TYSDKDDETN LPNVRSISLM
DLQDPNAAQC DPSSVMQDAP VRLSGSQLSV TQVANIKQLQ NTPQSAPQVR RPLHAAVNQQ
GSLQALSFRN PVYHLNNPPQ PMPKVSMDSS LENLSIPSSR SQNSEDLKLS GPSNSSMEDF
AKRSTHSEDF SRQGAILDKH MPIALPRQNS TGQAQIRKTG LGARVKTPQS LPHSASLRST
GSMSVASATM AAEPVQNGNR SRQQSSSSRE SPVPKVRAIQ QQQTQQSPVD SATMSPVERT
AAWVLNNGQY EEEEEDGEQN QDGTKHAEKY EQEITKLKDR LRVSNRRLEE YEQRLLVQEQ
QMQKLLMEYK TRLEDSEERL RKQQEEKDSQ MKVIISRLMA VEEELRNDHA EMEAVIEIKQ
RIIDAQERRI FSLDRSNTRL TKALAQVKER YSMQARNGIV SV
//
