ID H9GKN9_ANOCA Unreviewed; 344 AA.
AC H9GKN9;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=X-C motif chemokine receptor 1 {ECO:0000313|Ensembl:ENSACAP00000013839.2};
GN Name=XCR1 {ECO:0000313|Ensembl:ENSACAP00000013839.2};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000013839.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000013839.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000013839.2};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000013839.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_016851955.1; XM_016996466.1.
DR AlphaFoldDB; H9GKN9; -.
DR STRING; 28377.ENSACAP00000013839; -.
DR Ensembl; ENSACAT00000014122.2; ENSACAP00000013839.2; ENSACAG00000014112.2.
DR GeneID; 100559483; -.
DR KEGG; acs:100559483; -.
DR CTD; 2829; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01090000260052; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; H9GKN9; -.
DR OMA; RSHTKNR; -.
DR OrthoDB; 5394353at2759; -.
DR TreeFam; TF330966; -.
DR Proteomes; UP000001646; Unplaced.
DR Bgee; ENSACAG00000014112; Expressed in liver and 2 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR PANTHER; PTHR10489:SF730; CHEMOKINE XC RECEPTOR 1; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 73..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..298
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 344 AA; 39709 MW; 50F714C7C8305CC6 CRC64;
MAELTESTPN TTDYDYDELP ESNYCYMGDI SELSALLISI LYSVIFLFSL LGNSLVLRIV
LKYESLMSLT NLFIVNLCIS DLIFSCTLPF LIVYHSYGWI MGEFLCKAVS GIFSISYFCG
VIFLTIMTIL RYLAVVDPLS TLRTQKKRSG ILVSLAVWVT SLLFVIPEIL SIQVTTDIDG
RYGCYYQAFY PWEMVELCLK VLFFLISFMI IAICYTGMLD ILLRSRSQSR HRTVRLIFAI
VLVFFLSWAP YNVLGFVYAL SEQNVIESKC QTKKDIYFAF DISRTVAYCH CCLNPVLYVF
VGVKFRRHLK LLYKQYAQRH RAILPSSPRH HSSHADLYEE QSLY
//
