ID   H9GPQ7_ANOCA            Unreviewed;       345 AA.
AC   H9GPQ7;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=1-alkyl-2-acetylglycerophosphocholine esterase {ECO:0000256|ARBA:ARBA00013201};
DE            EC=3.1.1.47 {ECO:0000256|ARBA:ARBA00013201};
GN   Name=PAFAH2 {ECO:0000313|Ensembl:ENSACAP00000017536.3};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000017536.3, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000017536.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000017536.3};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000017536.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; H9GPQ7; -.
DR   STRING; 28377.ENSACAP00000017536; -.
DR   Ensembl; ENSACAT00000017882.4; ENSACAP00000017536.3; ENSACAG00000017809.4.
DR   eggNOG; KOG3847; Eukaryota.
DR   GeneTree; ENSGT00390000005233; -.
DR   HOGENOM; CLU_022501_0_0_1; -.
DR   InParanoid; H9GPQ7; -.
DR   TreeFam; TF313831; -.
DR   Proteomes; UP000001646; Unplaced.
DR   Bgee; ENSACAG00000017809; Expressed in kidney and 12 other cell types or tissues.
DR   GO; GO:0003847; F:1-alkyl-2-acetylglycerophosphocholine esterase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR016715; PAF_acetylhydro_eukaryote.
DR   PANTHER; PTHR10272; PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE; 1.
DR   PANTHER; PTHR10272:SF6; PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE 2, CYTOPLASMIC; 1.
DR   Pfam; PF03403; PAF-AH_p_II; 1.
DR   PIRSF; PIRSF018169; PAF_acetylhydrolase; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT   ACT_SITE        191
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR018169-1"
FT   ACT_SITE        214
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR018169-1"
FT   ACT_SITE        269
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR018169-1"
SQ   SEQUENCE   345 AA;  38830 MW;  0BA0DC352413E63E CRC64;
     GAEQPAWIPR YEYYYGLADY MNMNRKWFAP LLSVTFGSCK IPVNWNAPFR PSSHKYPLII
     FSHGLGAIRT VYSAICIEMA SRGFLVIALE HRDRSASATY FCKLDPEAPD LPGSQANEEW
     LSYRGVPKDQ KEFHFRNPQL HQRANECIRG LKLFRSIDAG KPPVNLLRTD FDLSALKDNI
     DLTKVAVMGH SFGGATSVLA LVKEAQFKCA VALDAWMFPL ENSLYPKVTK PVLFVNTESF
     QTPESVAKMK RISATSNESK IITILGSVHQ SQTDFTFLAG NLVNRVFQTR GTIDPYEGHR
     ITNQAALAFL QKHLQLKEDF DQWDHLLEGI GDCIVPDSPL QKSSL
//