GenomeNet

Database: UniProt
Entry: H9H1N9_MELGA
LinkDB: H9H1N9_MELGA
Original site: H9H1N9_MELGA 
ID   H9H1N9_MELGA            Unreviewed;      2660 AA.
AC   H9H1N9;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   25-OCT-2017, entry version 35.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 3 {ECO:0000313|Ensembl:ENSMGAP00000010211};
GN   Name=ITPR3 {ECO:0000313|Ensembl:ENSMGAP00000010211};
OS   Meleagris gallopavo (Common turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000010211, ECO:0000313|Proteomes:UP000001645};
RN   [1] {ECO:0000313|Ensembl:ENSMGAP00000010211, ECO:0000313|Proteomes:UP000001645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA   Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA   Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA   Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA   Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA   Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A.,
RA   de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D.,
RA   Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P.,
RA   Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S.,
RA   Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M.,
RA   Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S.,
RA   Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F.,
RA   Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P.,
RA   Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.;
RT   "Multi-platform next-generation sequencing of the domestic turkey
RT   (Meleagris gallopavo): genome assembly and analysis.";
RL   PLoS Biol. 8:E1000475-E1000475(2010).
RN   [2] {ECO:0000313|Ensembl:ENSMGAP00000010211}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMGAP00000010211}.
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DR   STRING; 9103.ENSMGAP00000010211; -.
DR   Ensembl; ENSMGAT00000011057; ENSMGAP00000010211; ENSMGAG00000009787.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H9H1N9; -.
DR   OMA; VVVFYND; -.
DR   OrthoDB; EOG091G00T2; -.
DR   TreeFam; TF312815; -.
DR   Proteomes; UP000001645; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:Ensembl.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR   GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR   GO; GO:0007613; P:memory; IEA:Ensembl.
DR   GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR   GO; GO:0050913; P:sensory perception of bitter taste; IEA:Ensembl.
DR   GO; GO:0050916; P:sensory perception of sweet taste; IEA:Ensembl.
DR   GO; GO:0050917; P:sensory perception of umami taste; IEA:Ensembl.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt-bd.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001645};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2191   2216       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2228   2246       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2258   2278       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2314   2339       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2359   2381       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2487   2510       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    173       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    224       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      295    372       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      378    434       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     2618   2645       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2660 AA;  304331 MW;  9B52EAFE63F14BEA CRC64;
     MNEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC
     PMNRYSAQKQ YWKAKQTKQD KEKIADVVLL QKLQHAAQME QKQNETENKK VHGDVVKYGS
     VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDATGNEGS WLFIQPFWKL RSNGDNVVVG
     DKVILNPVNA GQPLHASNYE LADNAGCKEV NSVNCNTSWK INLFMQFRDH MEEVLKGGDV
     VRLFHAEQEK FLTCDEYKGK LHVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
     NGLYRFKHLA TGNYLAAEEN PSYKGDVAEP KAAPTGGSSR SSRRNTGEKI KYRLVAVPHG
     NDIASLFELD PTTLQKTDSF VPRNSYVRLR HLCTNTWIQS TNVPIDIDEE RPIRLMLGTC
     PTKEDKEAFA IVSVPVSEIR DLDFANDASS MLANVVEKMN EGFLSQNDRR FVIQLLEDLV
     FFVSDVPNNG QNVLDIVVTK PNRERQKLMR EQNILKQIFG ILKAPFKDKG GEGPLVRLEE
     LSDQKNAPYQ YMFRLCYRVL RHSQEDYRKN QEHIAKQFGM MQSQIGYDIL AEDTITALLH
     NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NHIAIPVTQE LICKCVLDPK
     NSDILIKTEL RPVKEMSQTH EYLSIEYSEE EVWLTWTDKN NDHHEKSIRQ LAQEARAGNA
     HDENVLSYYR YQLKLFARMC LDRQYLAIKE ISQQLGVDLI FLCMADEMLP FDLRASFCHL
     MLHVHVDRDP QELVMPVKFA RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF ASTMEFVEDY
     LNNVVSEAVP FANEEKNKLT FEVVSLAHNL IYFGFYSFSE LLRLTRTLLG IIDCVQNPQL
     MMQAVYSDEV TGKNVRRSIQ GVGQMMSTMV LSRKQSIFSP PSLSAGSTPE PVDRGRSVEN
     ENIVVMETKL KILEILQFIL NVRLDYRISY LLSVFKKEFV EVYPMQDSAA DGTAPAFDST
     TAAMNLDRIG EHAEAMFGVG KTSSMLEVDD EGGRMFLRVL IHLTMHDYPP LISGSLQLLF
     KHFSQRQEVL HTFKQVQLLI SAQDVENYKV IKSELDKLRT MVEKSELWVD KKGSVKGDSN
     VDGNKKEKKE HTADEEVIAP GEKSSENYQI VKGILERLNK MCGVGEQVRK KQQRLLKNMD
     AHKVMLDLLQ IPYEKGDAKM MEILKFTHQF LQKFCAGNQE NQALLHKHLN LFLTPGLLEA
     ETMQHIFLNN YQLCSEINET VPQHFIHCVA THGRHVQYLD FLHTIIKAEG KYVKKCQDMI
     MTELTNAGDD VVVFYNDKAS LATLLEMMTA ARDGVEENSP LMYHISLVDL LAACAEGKNV
     YTEIKCTSLL PLEDVVRVVT HEDCITEVKM AYVNFVNHCY VDTEVEMKEI YTSNHIWTLF
     ENFTLDMAQM CKKREKRLPD PTLEKYVLTV VLDTINAFFS SPFSENSTSL QTHQTIVVQL
     LQSTMRLLEC PWLQQQHKSS VEACIRTLAM VAKSRSIALP MDLDAHVSSL LNSSSTSTVQ
     RNTSSYKTAT RTFPVSTTPN QWDYKNIIEK LQDIINALED RLKPLVEAEL SVLVDVLHRP
     ELLFMEGTEA YQRCESGGFL SKLVQHTKDL METEEKLCIK VLRTLQQMLV KRNKYGERGN
     LLRKMLLNNY LQNKKSSSKG EIVDAAGGGQ DQDWSAIAAV QCRLDREGAT KLVADLIMNT
     KNEKIFQESI LLAIRLLDGG NTEIQKSFYN LMTSDKKSEK FFKVLHDRMK KAQQETKSTV
     SVNMSDIGNK PREDKDEPDP GTKGRGETFM MPGTPSRYPL ALGFRKGHDT GEQGQNNEMG
     VTVLIMEPIL RFLQLLCENH NRDLQNFLRC QNNKTNYNLV CETLQFLDIM CGSTTGMDSS
     RDRASFGIHG MKARHHFGAG LCWMVKSCIV THESNGIDII TALILNDISP LCKYRMDLVL
     QLKDNASKLL LALMESRHDS ENAERILISL RPQELVDVIK KAYLQEEECE NAEVSPREVG
     HNIYILALQL SRHNKSLQQL LKPVKRIQEE EEEGISSMLS LNNKQLTQML KSTAPVQEEE
     EDPLAYYEKH TSQIEIVRLD RSMEQIIFPV PGICEFLTKE TKYRLFTTTE QDEQGSKVSD
     FFDQSSFLHN EMEWQKKLRS MPLMYWFSRR MTLWGSISFN LAVFINIIIA FFYPYVEATS
     MGVLDSPLIS LLFWILICFS IMALFTKRYG VRPLLVALIL RSIYYLGIGL TLNILGALNL
     TNKIVFVVSF VGNRGTFIRG YKAMIMDVEF LYHVGYILTS VLGLFVHELF YSILLFDLIY
     REETLFNVIK SVTRNGRSIL LTALLALILV YLFSIVGFLF LKDDFILEVD RLPDSKAQDD
     PLGMHRNMET FMESCSGDKI SCSAEPTALQ GVVEADTDQW ERACDTLLMC IVTVLNHGLR
     NGGGVGDILR KPSKDESLFP ARVVYDLLFF FIVIIIVLNL IFGVIIDTFA DLRSEKQKKE
     EILKTTCFIC GLERDKFDNK TVSFEEHIKY EHNMWNYLYF IVLVRVKNKT DYTGPESYVA
     QMIKNKNLDW FPRMRAMSLV SNEGEGEQNE IRNLQDKLNS TMKLVSHLTS QLNELKEQMT
     EQRKRRQRMG FVDVQNTMNH
//
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