ID H9H1V9_MELGA Unreviewed; 403 AA.
AC H9H1V9;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=sarcosine oxidasee (formaldehyde-forming) {ECO:0000256|ARBA:ARBA00012769};
DE EC=1.5.3.1 {ECO:0000256|ARBA:ARBA00012769};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000013432.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000013432.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000013432.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O2 + sarcosine = formaldehyde + glycine + H2O2;
CC Xref=Rhea:RHEA:13313, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16240, ChEBI:CHEBI:16842, ChEBI:CHEBI:57305,
CC ChEBI:CHEBI:57433; EC=1.5.3.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000323};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the MSOX/MTOX family.
CC {ECO:0000256|ARBA:ARBA00010989}.
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DR AlphaFoldDB; H9H1V9; -.
DR STRING; 9103.ENSMGAP00000013432; -.
DR Ensembl; ENSMGAT00000014339.3; ENSMGAP00000013432.3; ENSMGAG00000012736.3.
DR GeneTree; ENSGT00390000011000; -.
DR HOGENOM; CLU_007884_2_2_1; -.
DR TreeFam; TF313837; -.
DR Proteomes; UP000001645; Chromosome 21.
DR Bgee; ENSMGAG00000012736; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR045170; MTOX.
DR PANTHER; PTHR10961; PEROXISOMAL SARCOSINE OXIDASE; 1.
DR PANTHER; PTHR10961:SF7; PEROXISOMAL SARCOSINE OXIDASE; 1.
DR Pfam; PF01266; DAO; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT DOMAIN 53..382
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
SQ SEQUENCE 403 AA; 44192 MW; 8DD6684B900C06C1 CRC64;
MGHKLHWREK KTVSLRSGGL CPVPPPWLCS QLQEDRMGTD MAAPGQPRCT SYDAIVIGAG
IQGSFAAYHL AQRRRNTLLL EQFFLPHSRG SSHGQSRITR SAYPQEHYAH MMPHSFHLWQ
QLEDEAGIPL YRRTGLVVLG LPGDPKLEGC RRSMGPDAVL DAVTLAQRFP GLRPRPGEVA
LWDRSGGVLL ADRALRAVQD AFCRRGGTVR DGEKVLRIDP GAVITVTTTA GLYRAPRLII
AAGAWTNAVV APLGLRLPLQ PLRIDVCYWR EKEPGSGGAV TPCFMATGLP YAPHGIYGLP
ALEYPGLVKV CYHHGSPTDP EERDRIPSGS PRPHVSLLSN FISSYLPGLE PQPAVLESCL
YTNTPDGDFI LDQHPKYSNI IIGLASQAMG SNWPQWWGSC YAS
//
