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Database: UniProt
Entry: H9JES2_BOMMO
LinkDB: H9JES2_BOMMO
Original site: H9JES2_BOMMO 
ID   H9JES2_BOMMO            Unreviewed;       649 AA.
AC   H9JES2;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   07-JUN-2017, entry version 24.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Lepidoptera; Glossata; Ditrysia;
OC   Bombycoidea; Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091 {ECO:0000313|EnsemblMetazoa:BGIBMGA008019-TA, ECO:0000313|Proteomes:UP000005204};
RN   [1] {ECO:0000313|EnsemblMetazoa:BGIBMGA008019-TA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=p50T {ECO:0000313|EnsemblMetazoa:BGIBMGA008019-TA};
RX   PubMed=19121390; DOI=10.1016/j.ibmb.2008.11.004;
RG   International Silkworm Genome Consortium;
RT   "The genome of a lepidopteran model insect, the silkworm Bombyx
RT   mori.";
RL   Insect Biochem. Mol. Biol. 38:1036-1045(2008).
RN   [2] {ECO:0000313|EnsemblMetazoa:BGIBMGA008019-TA}
RP   IDENTIFICATION.
RC   STRAIN=p50T (Dazao) {ECO:0000313|EnsemblMetazoa:BGIBMGA008019-TA};
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; BABH01023381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BABH01023382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BABH01023383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BABH01023384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7091.BGIBMGA008019-TA; -.
DR   EnsemblMetazoa; BGIBMGA008019-RA; BGIBMGA008019-TA; BGIBMGA008019.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   InParanoid; H9JES2; -.
DR   OMA; TIPSFMN; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 3.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005204};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005204};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    274    300       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    312    337       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    395    416       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    423    441       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    461    483       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    577    600       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED        6     33       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   649 AA;  73295 MW;  B1CEC362BEC802DA CRC64;
     MHRSTNSCLK EKIDYIESEI QEMTKNARNL KSDYLSLIEL KLLIEKTQTF FQDHSAQRKL
     SATVQIYNND AVFGHLGFIA GTVATSRVPS FERMLWRISH GNIFFKQAQI DQPLKDPITG
     HELQKTVFVV FFHGEQIKLR VKKVLDQTEQ HRRLVLTNIA GDISTWMLAV RKEKAIYHTL
     NMFSMDIIKK CLIAECWVPK SDLYIAQKAL DDGVKASGSP IPSILHHVPT REIPPTFNRT
     NKFTRGFQTL IDSYGIASYR EVNPALYTII TFPFLFAVMF GDVGHGLIMT AFSAIIVIYE
     KRLSKNKSDN EIWNIFFAGR YIILLMGIFS VYTGLIYNDM FSKSLNLFGS SWMNVYDSET
     LANHTSLELD PAVAYTQTPY PFGLDPAWQF ATNNIIFLNS FQMKLSIIFG VLHMAFDPTY
     GTSCAPSVLI TFINMMLLKG SEDSPPCKAM MFDGQDALQK LFLTLGFLCI PIMLFGKPAF
     LFWQARNRKR HEVGGERGEV PAGAGGGAGA AGELLITQAI HTIEYVLGTV SHTASYLRLW
     ALSLAHAQLS AVLWQRVLRY GLARSLAGSV TMYVGFAVWA FFTLAILVLM EGLSAFLHTL
     RLHWVEFMSK FYDGQGYAFM PFSFAAIIEH DDEELAQNGA PPEKKDEEY
//
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