ID H9KV43_HUMAN Unreviewed; 204 AA.
AC H9KV43;
DT 16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Dynein axonemal heavy chain 14 {ECO:0000313|Ensembl:ENSP00000332424.6};
DE Flags: Fragment;
GN Name=DNAH14 {ECO:0000313|Ensembl:ENSP00000332424.6};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000332424.6, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000332424.6, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H.,
RA Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C.,
RA Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R.,
RA Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.,
RA Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.,
RA Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R.,
RA Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D.,
RA Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A.,
RA Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S.,
RA Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A.,
RA Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S.,
RA Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A.,
RA Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L.,
RA Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z.,
RA Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C.,
RA Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M.,
RA Langford C.F., Pandian R.D., Porter K.M., Prigmore E.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000332424.6}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC092811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL162738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL357912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL391811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL596134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL645769; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF455145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; H9KV43; -.
DR PeptideAtlas; H9KV43; -.
DR ProteomicsDB; 46202; -.
DR Antibodypedia; 34641; 94 antibodies from 15 providers.
DR Ensembl; ENST00000328556.9; ENSP00000332424.6; ENSG00000185842.16.
DR UCSC; uc057pwe.1; human.
DR HGNC; HGNC:2945; DNAH14.
DR VEuPathDB; HostDB:ENSG00000185842; -.
DR GeneTree; ENSGT00940000160505; -.
DR HOGENOM; CLU_1351626_0_0_1; -.
DR ChiTaRS; DNAH14; human.
DR Proteomes; UP000005640; Chromosome 1.
DR Bgee; ENSG00000185842; Expressed in left testis and 106 other cell types or tissues.
DR ExpressionAtlas; H9KV43; baseline and differential.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042228; Dynein_linker_3.
DR PANTHER; PTHR10676:SF356; DYNEIN AXONEMAL HEAVY CHAIN 14; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 178..203
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000332424.6"
FT NON_TER 204
FT /evidence="ECO:0000313|Ensembl:ENSP00000332424.6"
SQ SEQUENCE 204 AA; 23595 MW; 1DBCBA16E8165357 CRC64;
XMLISAEGEG LVLPKKIRVR SAVEQWLVNV EKSMFDVLKK FLSQGIEDWN CQMFSQWVLS
HPGQVVLTVS QIMFYNDCVK SFVSSYSREK LEKVHAGLMC HLEEVADLVV LDTSNSRTKA
ILGALLILYV HCRDIVINLL LKNIFNAEDF EWTRHLQYKW NEKQKLCYVS QGNASFTYGY
EYLGCTSRLV ITPLTDRCWL TLME
//
