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Database: UniProt
Entry: H9MH62_9RODE
LinkDB: H9MH62_9RODE
Original site: H9MH62_9RODE 
ID   H9MH62_9RODE            Unreviewed;       246 AA.
AC   H9MH62;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   22-FEB-2023, entry version 31.
DE   RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE            Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE   Flags: Fragment;
GN   Name=BDNF {ECO:0000313|EMBL:AEY99493.1};
OS   Hypogeomys antimena (Malagasy giant rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Nesomyidae; Nesomyinae; Hypogeomys.
OX   NCBI_TaxID=89379 {ECO:0000313|EMBL:AEY99493.1};
RN   [1] {ECO:0000313|EMBL:AEY99493.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22431616; DOI=10.1073/pnas.1112487109;
RA   Crottini A., Madsen O., Poux C., Strauss A., Vieites D.R., Vences M.;
RT   "Vertebrate time-tree elucidates the biogeographic pattern of a major
RT   biotic change around the K-T boundary in Madagascar.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:5358-5363(2012).
CC   -!- FUNCTION: During development, promotes the survival and differentiation
CC       of selected neuronal populations of the peripheral and central nervous
CC       systems. Participates in axonal growth, pathfinding and in the
CC       modulation of dendritic growth and morphology. Major regulator of
CC       synaptic transmission and plasticity at adult synapses in many regions
CC       of the CNS. {ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
CC       {ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR   EMBL; JQ073055; AEY99493.1; -; Genomic_DNA.
DR   AlphaFoldDB; H9MH62; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589:SF3; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR001789-1};
KW   Growth factor {ECO:0000256|RuleBase:RU364086};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|RuleBase:RU364086}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|RuleBase:RU364086"
FT   CHAIN           17..246
FT                   /note="Brain-derived neurotrophic factor"
FT                   /evidence="ECO:0000256|RuleBase:RU364086"
FT                   /id="PRO_5010897307"
FT   DOMAIN          132..239
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   DISULFID        140..207
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT   DISULFID        185..236
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT   DISULFID        195..238
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AEY99493.1"
FT   NON_TER         246
FT                   /evidence="ECO:0000313|EMBL:AEY99493.1"
SQ   SEQUENCE   246 AA;  27735 MW;  3888AEC9CB033870 CRC64;
     ILFLTMVISY FGCMKAAPMK EANVHGQGSL AYPGVRTHGT LESVNGPRAG SRGLTTSLAD
     TFEHVIEELL DEDQKVRPNE ENHKDADLYT SRVMLSSQVP LEPPLLFLLE EYKNYLDAAN
     MSMRVRRHSD PARRGELSVC DSISEWVTAA DKKTAVDMSG GTVTVLEKVP VSKGQLKQYF
     YETKCNPMGY TKEGCRGIDK RHWNSQCRTT QSYVRALTMD SKKRIGWRFI RIDTSCVCTL
     TIKRGR
//
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