ID H9MH62_9RODE Unreviewed; 246 AA.
AC H9MH62;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 22-FEB-2023, entry version 31.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:AEY99493.1};
OS Hypogeomys antimena (Malagasy giant rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Nesomyidae; Nesomyinae; Hypogeomys.
OX NCBI_TaxID=89379 {ECO:0000313|EMBL:AEY99493.1};
RN [1] {ECO:0000313|EMBL:AEY99493.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22431616; DOI=10.1073/pnas.1112487109;
RA Crottini A., Madsen O., Poux C., Strauss A., Vieites D.R., Vences M.;
RT "Vertebrate time-tree elucidates the biogeographic pattern of a major
RT biotic change around the K-T boundary in Madagascar.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:5358-5363(2012).
CC -!- FUNCTION: During development, promotes the survival and differentiation
CC of selected neuronal populations of the peripheral and central nervous
CC systems. Participates in axonal growth, pathfinding and in the
CC modulation of dendritic growth and morphology. Major regulator of
CC synaptic transmission and plasticity at adult synapses in many regions
CC of the CNS. {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
CC {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; JQ073055; AEY99493.1; -; Genomic_DNA.
DR AlphaFoldDB; H9MH62; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF3; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU364086};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|RuleBase:RU364086}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|RuleBase:RU364086"
FT CHAIN 17..246
FT /note="Brain-derived neurotrophic factor"
FT /evidence="ECO:0000256|RuleBase:RU364086"
FT /id="PRO_5010897307"
FT DOMAIN 132..239
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 140..207
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 185..236
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 195..238
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEY99493.1"
FT NON_TER 246
FT /evidence="ECO:0000313|EMBL:AEY99493.1"
SQ SEQUENCE 246 AA; 27735 MW; 3888AEC9CB033870 CRC64;
ILFLTMVISY FGCMKAAPMK EANVHGQGSL AYPGVRTHGT LESVNGPRAG SRGLTTSLAD
TFEHVIEELL DEDQKVRPNE ENHKDADLYT SRVMLSSQVP LEPPLLFLLE EYKNYLDAAN
MSMRVRRHSD PARRGELSVC DSISEWVTAA DKKTAVDMSG GTVTVLEKVP VSKGQLKQYF
YETKCNPMGY TKEGCRGIDK RHWNSQCRTT QSYVRALTMD SKKRIGWRFI RIDTSCVCTL
TIKRGR
//