ID H9MHC2_9SAUR Unreviewed; 237 AA.
AC H9MHC2;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:AEY99553.1};
OS Lygodactylus sp. AC-2011.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Gekkota; Gekkonidae; Gekkoninae;
OC Lygodactylus.
OX NCBI_TaxID=1127731 {ECO:0000313|EMBL:AEY99553.1};
RN [1] {ECO:0000313|EMBL:AEY99553.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22431616; DOI=10.1073/pnas.1112487109;
RA Crottini A., Madsen O., Poux C., Strauss A., Vieites D.R., Vences M.;
RT "Vertebrate time-tree elucidates the biogeographic pattern of a major
RT biotic change around the K-T boundary in Madagascar.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:5358-5363(2012).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|ARBA:ARBA00002323, ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; JQ073115; AEY99553.1; -; Genomic_DNA.
DR AlphaFoldDB; H9MHC2; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 126..233
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 134..201
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 179..230
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 189..232
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEY99553.1"
FT NON_TER 237
FT /evidence="ECO:0000313|EMBL:AEY99553.1"
SQ SEQUENCE 237 AA; 26791 MW; 549D7543AB86412A CRC64;
TMVISYFSCM KAAPMKEVSI RGQGSLAYPG LRTQGTLENL DGPNDASRGL TSLADTFEHV
IEELLDEQQD LQPNKENKDA DLYSSRVMLS SQVPLEPPLL FLLEEYKNYL DAANMSMRVR
RHSDPARRGE LSVCDSTSEW VTAAEKKTAV DMSGATVTVL EKVPVPKGQL KQYFYETKCN
SKGYTKEGCR GIDKRYWNSQ CRTTQSYVRA LTMDNKKRVG WRFIRIDTSC VCTLTIK
//
