ID H9NEW0_9VIRU Unreviewed; 281 AA.
AC H9NEW0;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 03-MAY-2023, entry version 35.
DE RecName: Full=Non-structural polyprotein 1AB {ECO:0000256|ARBA:ARBA00019743};
DE Flags: Fragment;
GN Name=ORF1b {ECO:0000313|EMBL:AFF57941.1};
OS Astrovirus CDB-2012.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC Stellavirales; Astroviridae.
OX NCBI_TaxID=1166568 {ECO:0000313|EMBL:AFF57941.1};
RN [1] {ECO:0000313|EMBL:AFF57941.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1456 {ECO:0000313|EMBL:AFF57941.1};
RX PubMed=22527867; DOI=10.1007/s00705-012-1311-1;
RA De Battisti C., Salviato A., Jonassen C.M., Toffan A., Capua I.,
RA Cattoli G.;
RT "Genetic characterization of astroviruses detected in guinea fowl (Numida
RT meleagris) reveals a distinct genotype and suggests cross-species
RT transmission between turkey and guinea fowl.";
RL Arch. Virol. 157:1329-1337(2012).
CC -!- FUNCTION: Contains the viral protease participating in the cleavage of
CC the polyprotein into functional products. It contains also the
CC activities necessary for replication of genomic RNA, as well as
CC transcription of subgenomic mRNA. {ECO:0000256|ARBA:ARBA00029407}.
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000256|ARBA:ARBA00004301};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004301}.
CC -!- SIMILARITY: Belongs to the astroviridae polyprotein 1AB family.
CC {ECO:0000256|ARBA:ARBA00005873}.
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DR EMBL; JQ307831; AFF57941.1; -; Genomic_RNA.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23172; ps-ssRNAv_Astroviridae_RdRp; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF00680; RdRP_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Ribosomal frameshifting {ECO:0000256|ARBA:ARBA00022758};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 24..158
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFF57941.1"
SQ SEQUENCE 281 AA; 32977 MW; 141C7520D83F0F00 CRC64;
QVGWTPFFGG LDRRVRRLYG DGDRYFVEMD WTRYDGTIPK SLFWRIRQIR FFFLHDSHKT
PKMRRLYNWY VKNLLEKIIL LPTGEVCQVK KGNPSGQYST TVDNNMINVW LTTFEISYLF
FKQRGRLPTE KELQENCSMI CYGDDRLLSI RKGFVEYEPE TVIEMYKNIF GMWVKRSNIK
IQDTPEGLSF CGLTIVKSST GAYVGVPNVN KILSTLENPV RRLPDVESLW GKLVSLRILC
ENAPNNVKHF LDEQISNVEE FAARENIQLP EVGPDFYSRI W
//
