ID H9NHF3_9PAPI Unreviewed; 148 AA.
AC H9NHF3;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=Protein E6 {ECO:0000256|HAMAP-Rule:MF_04006, ECO:0000256|RuleBase:RU363123};
GN Name=E6 {ECO:0000256|HAMAP-Rule:MF_04006,
GN ECO:0000313|EMBL:AFF58877.1};
OS Human papillomavirus.
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Zurhausenvirales; Papillomaviridae.
OX NCBI_TaxID=10566 {ECO:0000313|EMBL:AFF58877.1};
RN [1] {ECO:0000313|EMBL:AFF58857.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E6-1 {ECO:0000313|EMBL:AFF58857.1}, E6-10
RC {ECO:0000313|EMBL:AFF58866.1}, E6-11 {ECO:0000313|EMBL:AFF58867.1},
RC E6-15 {ECO:0000313|EMBL:AFF58871.1}, E6-16
RC {ECO:0000313|EMBL:AFF58872.1}, E6-2 {ECO:0000313|EMBL:AFF58858.1},
RC E6-6 {ECO:0000313|EMBL:AFF58862.1}, and E6-9
RC {ECO:0000313|EMBL:AFF58865.1};
RX PubMed=14624377; DOI=10.1086/379198;
RG Canadian Women's HIV Study Group;
RA Aho J., Hankins C., Tremblay C., Lang F., Forest P., Pourreaux K.,
RA Rouah F., Coutlee F.;
RT "Molecular analysis of human papillomavirus type 52 isolates detected in
RT the genital tract of human immunodeficiency virus-seropositive and
RT -seronegative women.";
RL J. Infect. Dis. 188:1517-1527(2003).
RN [2] {ECO:0000313|EMBL:AFF58857.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E6-1 {ECO:0000313|EMBL:AFF58857.1}, E6-10
RC {ECO:0000313|EMBL:AFF58866.1}, E6-11 {ECO:0000313|EMBL:AFF58867.1},
RC E6-15 {ECO:0000313|EMBL:AFF58871.1}, E6-16
RC {ECO:0000313|EMBL:AFF58872.1}, E6-2 {ECO:0000313|EMBL:AFF58858.1},
RC E6-6 {ECO:0000313|EMBL:AFF58862.1}, and E6-9
RC {ECO:0000313|EMBL:AFF58865.1};
RX PubMed=15195242; DOI=10.1086/420787;
RG Canadian Women's HIV Study Group;
RA Aho J., Hankins C., Tremblay C., Forest P., Pourreaux K., Rouah F.,
RA Coutlee F.;
RT "Genomic polymorphism of human papillomavirus type 52 predisposes toward
RT persistent infection in sexually active women.";
RL J. Infect. Dis. 190:46-52(2004).
RN [3] {ECO:0000313|EMBL:AFF58877.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MTL-52-E6-19 {ECO:0000313|EMBL:AFF58875.1}, MTL-52-E6-21
RC {ECO:0000313|EMBL:AFF58877.1}, and MTL-52-E6-22
RC {ECO:0000313|EMBL:AFF58878.1};
RA Formentin A., Brassard P., Franco E.L., Coutlee F.;
RT "Human Papillomavirus type 52 polymorphism and cancer.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AFF58857.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E6-1 {ECO:0000313|EMBL:AFF58857.1}, E6-10
RC {ECO:0000313|EMBL:AFF58866.1}, E6-11 {ECO:0000313|EMBL:AFF58867.1},
RC E6-15 {ECO:0000313|EMBL:AFF58871.1}, E6-16
RC {ECO:0000313|EMBL:AFF58872.1}, E6-2 {ECO:0000313|EMBL:AFF58858.1},
RC E6-6 {ECO:0000313|EMBL:AFF58862.1}, and E6-9
RC {ECO:0000313|EMBL:AFF58865.1};
RA Aho J., Formentin A., Hankins C., Money D., Coutlee F.;
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a major role in the induction and maintenance of
CC cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-
CC protein ligase and modulates its activity. Protects host keratinocytes
CC from apoptosis by mediating the degradation of host BAK1. May also
CC inhibit host immune response. {ECO:0000256|HAMAP-Rule:MF_04006}.
CC -!- SUBUNIT: Forms homodimers. Interacts with ubiquitin-protein ligase
CC UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity.
CC Interacts with host BAK1. {ECO:0000256|HAMAP-Rule:MF_04006}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04006,
CC ECO:0000256|RuleBase:RU363123}. Host nucleus {ECO:0000256|HAMAP-
CC Rule:MF_04006, ECO:0000256|RuleBase:RU363123}.
CC -!- SIMILARITY: Belongs to the papillomaviridae E6 protein family.
CC {ECO:0000256|ARBA:ARBA00006346, ECO:0000256|HAMAP-Rule:MF_04006,
CC ECO:0000256|RuleBase:RU363123}.
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DR EMBL; JQ293063; AFF58857.1; -; Genomic_DNA.
DR EMBL; JQ293064; AFF58858.1; -; Genomic_DNA.
DR EMBL; JQ293068; AFF58862.1; -; Genomic_DNA.
DR EMBL; JQ293071; AFF58865.1; -; Genomic_DNA.
DR EMBL; JQ293072; AFF58866.1; -; Genomic_DNA.
DR EMBL; JQ293073; AFF58867.1; -; Genomic_DNA.
DR EMBL; JQ293077; AFF58871.1; -; Genomic_DNA.
DR EMBL; JQ293078; AFF58872.1; -; Genomic_DNA.
DR EMBL; JQ293081; AFF58875.1; -; Genomic_DNA.
DR EMBL; JQ293083; AFF58877.1; -; Genomic_DNA.
DR EMBL; JQ293084; AFF58878.1; -; Genomic_DNA.
DR SMR; H9NHF3; -.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0039648; P:modulation by symbiont of host protein ubiquitination; IEA:UniProtKB-UniRule.
DR GO; GO:0039526; P:perturbation by virus of host apoptosis; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.240.40; E6 early regulatory protein; 2.
DR HAMAP; MF_04006; HPV_E6; 1.
DR InterPro; IPR001334; E6.
DR InterPro; IPR038575; E6_sf.
DR Pfam; PF00518; E6; 1.
DR SUPFAM; SSF161229; E6 C-terminal domain-like; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|HAMAP-Rule:MF_04006, ECO:0000256|RuleBase:RU363123};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_04006,
KW ECO:0000256|RuleBase:RU363123};
KW Early protein {ECO:0000256|HAMAP-Rule:MF_04006,
KW ECO:0000256|RuleBase:RU363123};
KW Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04006};
KW Host nucleus {ECO:0000256|HAMAP-Rule:MF_04006,
KW ECO:0000256|RuleBase:RU363123};
KW Host-virus interaction {ECO:0000256|HAMAP-Rule:MF_04006};
KW Inhibition of host innate immune response by virus {ECO:0000256|HAMAP-
KW Rule:MF_04006};
KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_04006,
KW ECO:0000256|RuleBase:RU363123};
KW Modulation of host cell apoptosis by virus {ECO:0000256|ARBA:ARBA00023323,
KW ECO:0000256|HAMAP-Rule:MF_04006};
KW Transcription {ECO:0000256|HAMAP-Rule:MF_04006,
KW ECO:0000256|RuleBase:RU363123};
KW Transcription regulation {ECO:0000256|HAMAP-Rule:MF_04006,
KW ECO:0000256|RuleBase:RU363123};
KW Viral immunoevasion {ECO:0000256|HAMAP-Rule:MF_04006};
KW Zinc {ECO:0000256|HAMAP-Rule:MF_04006, ECO:0000256|RuleBase:RU363123};
KW Zinc-finger {ECO:0000256|HAMAP-Rule:MF_04006,
KW ECO:0000256|RuleBase:RU363123}.
FT ZN_FING 30..66
FT /evidence="ECO:0000256|HAMAP-Rule:MF_04006"
FT ZN_FING 103..139
FT /evidence="ECO:0000256|HAMAP-Rule:MF_04006"
FT MOTIF 146..148
FT /note="PDZ-binding domain"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_04006"
SQ SEQUENCE 148 AA; 17898 MW; C5E9DECE341AB0DE CRC64;
MFEDPATRPR TLHELCEVLE ESVHEIRLQC VQCKKELQRR EVYKFLFTDL RIVYRDNNPY
GVCIMCLRFL SKISEYRHYQ YSLYGKTLEE RVKKPLSEIT IRCIICQTPL CPEEKERHVN
ANKRFHNIMG RWTGRCSECW RPRPVTQV
//