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Database: UniProt
Entry: H9NHF3_9PAPI
LinkDB: H9NHF3_9PAPI
Original site: H9NHF3_9PAPI 
ID   H9NHF3_9PAPI            Unreviewed;       148 AA.
AC   H9NHF3;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   RecName: Full=Protein E6 {ECO:0000256|HAMAP-Rule:MF_04006, ECO:0000256|RuleBase:RU363123};
GN   Name=E6 {ECO:0000256|HAMAP-Rule:MF_04006,
GN   ECO:0000313|EMBL:AFF58877.1};
OS   Human papillomavirus.
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae.
OX   NCBI_TaxID=10566 {ECO:0000313|EMBL:AFF58877.1};
RN   [1] {ECO:0000313|EMBL:AFF58857.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=E6-1 {ECO:0000313|EMBL:AFF58857.1}, E6-10
RC   {ECO:0000313|EMBL:AFF58866.1}, E6-11 {ECO:0000313|EMBL:AFF58867.1},
RC   E6-15 {ECO:0000313|EMBL:AFF58871.1}, E6-16
RC   {ECO:0000313|EMBL:AFF58872.1}, E6-2 {ECO:0000313|EMBL:AFF58858.1},
RC   E6-6 {ECO:0000313|EMBL:AFF58862.1}, and E6-9
RC   {ECO:0000313|EMBL:AFF58865.1};
RX   PubMed=14624377; DOI=10.1086/379198;
RG   Canadian Women's HIV Study Group;
RA   Aho J., Hankins C., Tremblay C., Lang F., Forest P., Pourreaux K.,
RA   Rouah F., Coutlee F.;
RT   "Molecular analysis of human papillomavirus type 52 isolates detected in
RT   the genital tract of human immunodeficiency virus-seropositive and
RT   -seronegative women.";
RL   J. Infect. Dis. 188:1517-1527(2003).
RN   [2] {ECO:0000313|EMBL:AFF58857.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=E6-1 {ECO:0000313|EMBL:AFF58857.1}, E6-10
RC   {ECO:0000313|EMBL:AFF58866.1}, E6-11 {ECO:0000313|EMBL:AFF58867.1},
RC   E6-15 {ECO:0000313|EMBL:AFF58871.1}, E6-16
RC   {ECO:0000313|EMBL:AFF58872.1}, E6-2 {ECO:0000313|EMBL:AFF58858.1},
RC   E6-6 {ECO:0000313|EMBL:AFF58862.1}, and E6-9
RC   {ECO:0000313|EMBL:AFF58865.1};
RX   PubMed=15195242; DOI=10.1086/420787;
RG   Canadian Women's HIV Study Group;
RA   Aho J., Hankins C., Tremblay C., Forest P., Pourreaux K., Rouah F.,
RA   Coutlee F.;
RT   "Genomic polymorphism of human papillomavirus type 52 predisposes toward
RT   persistent infection in sexually active women.";
RL   J. Infect. Dis. 190:46-52(2004).
RN   [3] {ECO:0000313|EMBL:AFF58877.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MTL-52-E6-19 {ECO:0000313|EMBL:AFF58875.1}, MTL-52-E6-21
RC   {ECO:0000313|EMBL:AFF58877.1}, and MTL-52-E6-22
RC   {ECO:0000313|EMBL:AFF58878.1};
RA   Formentin A., Brassard P., Franco E.L., Coutlee F.;
RT   "Human Papillomavirus type 52 polymorphism and cancer.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AFF58857.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=E6-1 {ECO:0000313|EMBL:AFF58857.1}, E6-10
RC   {ECO:0000313|EMBL:AFF58866.1}, E6-11 {ECO:0000313|EMBL:AFF58867.1},
RC   E6-15 {ECO:0000313|EMBL:AFF58871.1}, E6-16
RC   {ECO:0000313|EMBL:AFF58872.1}, E6-2 {ECO:0000313|EMBL:AFF58858.1},
RC   E6-6 {ECO:0000313|EMBL:AFF58862.1}, and E6-9
RC   {ECO:0000313|EMBL:AFF58865.1};
RA   Aho J., Formentin A., Hankins C., Money D., Coutlee F.;
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a major role in the induction and maintenance of
CC       cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin-
CC       protein ligase and modulates its activity. Protects host keratinocytes
CC       from apoptosis by mediating the degradation of host BAK1. May also
CC       inhibit host immune response. {ECO:0000256|HAMAP-Rule:MF_04006}.
CC   -!- SUBUNIT: Forms homodimers. Interacts with ubiquitin-protein ligase
CC       UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity.
CC       Interacts with host BAK1. {ECO:0000256|HAMAP-Rule:MF_04006}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04006,
CC       ECO:0000256|RuleBase:RU363123}. Host nucleus {ECO:0000256|HAMAP-
CC       Rule:MF_04006, ECO:0000256|RuleBase:RU363123}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E6 protein family.
CC       {ECO:0000256|ARBA:ARBA00006346, ECO:0000256|HAMAP-Rule:MF_04006,
CC       ECO:0000256|RuleBase:RU363123}.
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DR   EMBL; JQ293063; AFF58857.1; -; Genomic_DNA.
DR   EMBL; JQ293064; AFF58858.1; -; Genomic_DNA.
DR   EMBL; JQ293068; AFF58862.1; -; Genomic_DNA.
DR   EMBL; JQ293071; AFF58865.1; -; Genomic_DNA.
DR   EMBL; JQ293072; AFF58866.1; -; Genomic_DNA.
DR   EMBL; JQ293073; AFF58867.1; -; Genomic_DNA.
DR   EMBL; JQ293077; AFF58871.1; -; Genomic_DNA.
DR   EMBL; JQ293078; AFF58872.1; -; Genomic_DNA.
DR   EMBL; JQ293081; AFF58875.1; -; Genomic_DNA.
DR   EMBL; JQ293083; AFF58877.1; -; Genomic_DNA.
DR   EMBL; JQ293084; AFF58878.1; -; Genomic_DNA.
DR   SMR; H9NHF3; -.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006351; P:DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   GO; GO:0039648; P:modulation by symbiont of host protein ubiquitination; IEA:UniProtKB-UniRule.
DR   GO; GO:0039526; P:perturbation by virus of host apoptosis; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.240.40; E6 early regulatory protein; 2.
DR   HAMAP; MF_04006; HPV_E6; 1.
DR   InterPro; IPR001334; E6.
DR   InterPro; IPR038575; E6_sf.
DR   Pfam; PF00518; E6; 1.
DR   SUPFAM; SSF161229; E6 C-terminal domain-like; 2.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|HAMAP-Rule:MF_04006, ECO:0000256|RuleBase:RU363123};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_04006,
KW   ECO:0000256|RuleBase:RU363123};
KW   Early protein {ECO:0000256|HAMAP-Rule:MF_04006,
KW   ECO:0000256|RuleBase:RU363123};
KW   Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04006};
KW   Host nucleus {ECO:0000256|HAMAP-Rule:MF_04006,
KW   ECO:0000256|RuleBase:RU363123};
KW   Host-virus interaction {ECO:0000256|HAMAP-Rule:MF_04006};
KW   Inhibition of host innate immune response by virus {ECO:0000256|HAMAP-
KW   Rule:MF_04006};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_04006,
KW   ECO:0000256|RuleBase:RU363123};
KW   Modulation of host cell apoptosis by virus {ECO:0000256|ARBA:ARBA00023323,
KW   ECO:0000256|HAMAP-Rule:MF_04006};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_04006,
KW   ECO:0000256|RuleBase:RU363123};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_04006,
KW   ECO:0000256|RuleBase:RU363123};
KW   Viral immunoevasion {ECO:0000256|HAMAP-Rule:MF_04006};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_04006, ECO:0000256|RuleBase:RU363123};
KW   Zinc-finger {ECO:0000256|HAMAP-Rule:MF_04006,
KW   ECO:0000256|RuleBase:RU363123}.
FT   ZN_FING         30..66
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_04006"
FT   ZN_FING         103..139
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_04006"
FT   MOTIF           146..148
FT                   /note="PDZ-binding domain"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_04006"
SQ   SEQUENCE   148 AA;  17898 MW;  C5E9DECE341AB0DE CRC64;
     MFEDPATRPR TLHELCEVLE ESVHEIRLQC VQCKKELQRR EVYKFLFTDL RIVYRDNNPY
     GVCIMCLRFL SKISEYRHYQ YSLYGKTLEE RVKKPLSEIT IRCIICQTPL CPEEKERHVN
     ANKRFHNIMG RWTGRCSECW RPRPVTQV
//
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