ID H9NL36_BACTU Unreviewed; 431 AA.
AC H9NL36;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 13-SEP-2023, entry version 41.
DE RecName: Full=dihydroxy-acid dehydratase {ECO:0000256|ARBA:ARBA00029490};
DE EC=4.2.1.9 {ECO:0000256|ARBA:ARBA00029490};
DE Flags: Fragment;
GN Name=ilvD {ECO:0000313|EMBL:AFF60370.1};
OS Bacillus thuringiensis serovar poloniensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=180894 {ECO:0000313|EMBL:AFF60370.1};
RN [1] {ECO:0000313|EMBL:AFF60370.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IEBC-T54 001 {ECO:0000313|EMBL:AFF60370.1};
RX PubMed=23073664; DOI=10.1007/s10482-012-9800-5;
RA Soufiane B., Baizet M., Cote J.C.;
RT "Multilocus sequence analysis of Bacillus thuringiensis serovars
RT navarrensis, bolivia and vazensis and Bacillus weihenstephanensis reveals a
RT common phylogeny.";
RL Antonie Van Leeuwenhoek 103:195-205(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate
CC + H2O; Xref=Rhea:RHEA:24809, ChEBI:CHEBI:11851, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:49072; EC=4.2.1.9;
CC Evidence={ECO:0000256|ARBA:ARBA00029304};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24810;
CC Evidence={ECO:0000256|ARBA:ARBA00029304};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|ARBA:ARBA00034078};
CC -!- PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-
CC isoleucine from 2-oxobutanoate: step 3/4.
CC {ECO:0000256|ARBA:ARBA00029437}.
CC -!- PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine from
CC pyruvate: step 3/4. {ECO:0000256|ARBA:ARBA00029436}.
CC -!- SIMILARITY: Belongs to the IlvD/Edd family.
CC {ECO:0000256|ARBA:ARBA00006486}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JQ728624; AFF60370.1; -; Genomic_DNA.
DR AlphaFoldDB; H9NL36; -.
DR UniPathway; UPA00047; UER00057.
DR UniPathway; UPA00049; UER00061.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0004160; F:dihydroxy-acid dehydratase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0009099; P:valine biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.50.30.80; IlvD/EDD C-terminal domain-like; 1.
DR InterPro; IPR042096; Dihydro-acid_dehy_C.
DR InterPro; IPR004404; DihydroxyA_deHydtase.
DR InterPro; IPR000581; DiOHA_6PGluconate_deHydtase.
DR InterPro; IPR020558; DiOHA_6PGluconate_deHydtase_CS.
DR InterPro; IPR037237; IlvD/EDD_N.
DR NCBIfam; TIGR00110; ilvD; 1.
DR PANTHER; PTHR43661; D-XYLONATE DEHYDRATASE; 1.
DR PANTHER; PTHR43661:SF3; D-XYLONATE DEHYDRATASE YAGF-RELATED; 1.
DR Pfam; PF00920; ILVD_EDD; 1.
DR SUPFAM; SSF143975; IlvD/EDD N-terminal domain-like; 1.
DR SUPFAM; SSF52016; LeuD/IlvD-like; 1.
DR PROSITE; PS00886; ILVD_EDD_1; 1.
DR PROSITE; PS00887; ILVD_EDD_2; 1.
PE 3: Inferred from homology;
KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Branched-chain amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFF60370.1"
FT NON_TER 431
FT /evidence="ECO:0000313|EMBL:AFF60370.1"
SQ SEQUENCE 431 AA; 46018 MW; 4388E55F4DE4A3DF CRC64;
ADSVETVVNA HWFDGMICIP NCDKITPGMM MAALRINIPT VFVSGGPMAA GKTSKGEVVD
LSSVFEGVGA YQSGKISEEE LKDIEDHGCP SCGSCSGMFT ANSMNCLCEV LGLALPGNGS
ILAIDPRREE LIKQAAEKLK ILIERDIKPR DIVTEEAIDD AFALDMAMGG STNTVLHTLA
LAQEAGLDYD MSRIDAVSRR VPHLCKVSPA SNWHMEDIDR AGGISAILKE MSRKEGVLHL
DRITATGQTL RENIAHAEIK DKEVIHSLEN PHSEEGGLRI LKGNLAKDGA VIKSGATEVK
RFEGPCVIFN SQDEALAGIM LGKVKKGDVV VIRYEGPRGG PGMPEMLAPT SAIAGMGLGA
DVALLTDGRF SGASRGISVG HISPEAAAGG TIALLEQGDI VCIDVEERLL EVRVSDEELD
KRKKEWKRPE P
//