ID H9XFN0_FRG3V Unreviewed; 164 AA.
AC H9XFN0;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 08-NOV-2023, entry version 34.
DE RecName: Full=dUTP diphosphatase {ECO:0000256|ARBA:ARBA00012379};
DE EC=3.6.1.23 {ECO:0000256|ARBA:ARBA00012379};
GN Name=ORF67R {ECO:0000313|EMBL:AFG73109.1};
OS Rana grylio iridovirus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Pimascovirales; Iridoviridae; Alphairidovirinae; Ranavirus; Frog virus 3.
OX NCBI_TaxID=380178 {ECO:0000313|EMBL:AFG73109.1, ECO:0000313|Proteomes:UP000168991};
RN [1] {ECO:0000313|EMBL:AFG73109.1, ECO:0000313|Proteomes:UP000168991}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22543635; DOI=10.1007/s00705-012-1316-9;
RA Lei X.Y., Ou T., Zhu R.L., Zhang Q.Y.;
RT "Sequencing and analysis of the complete genome of Rana grylio virus
RT (RGV).";
RL Arch. Virol. 157:1559-1564(2012).
CC -!- FUNCTION: This enzyme is involved in nucleotide metabolism: it produces
CC dUMP, the immediate precursor of thymidine nucleotides and it decreases
CC the intracellular concentration of dUTP so that uracil cannot be
CC incorporated into DNA. {ECO:0000256|ARBA:ARBA00003495}.
CC -!- SIMILARITY: Belongs to the dUTPase family.
CC {ECO:0000256|ARBA:ARBA00006581}.
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DR EMBL; JQ654586; AFG73109.1; -; Genomic_DNA.
DR Proteomes; UP000168991; Genome.
DR GO; GO:0004170; F:dUTP diphosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0006226; P:dUMP biosynthetic process; IEA:InterPro.
DR GO; GO:0046081; P:dUTP catabolic process; IEA:InterPro.
DR CDD; cd07557; trimeric_dUTPase; 1.
DR Gene3D; 2.70.40.10; -; 1.
DR InterPro; IPR008181; dUTPase.
DR InterPro; IPR029054; dUTPase-like.
DR InterPro; IPR036157; dUTPase-like_sf.
DR InterPro; IPR033704; dUTPase_trimeric.
DR NCBIfam; TIGR00576; dut; 1.
DR PANTHER; PTHR11241; DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE; 1.
DR PANTHER; PTHR11241:SF0; DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE; 1.
DR Pfam; PF00692; dUTPase; 1.
DR SUPFAM; SSF51283; dUTPase-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 20..142
FT /note="dUTPase-like"
FT /evidence="ECO:0000259|Pfam:PF00692"
SQ SEQUENCE 164 AA; 17381 MW; 6E1CB0E09D660C64 CRC64;
MHGNSLQYVK LSEHASGLIR GSAGAAGYDL AAAHPVVVPS FGRALVKTDL AVKMPPGLYG
RVAPRSGLAL KNFIDVGAGV VDPDYRGNLG VILFNFGCDP FRVKRGDRIA QLVLERYESP
PILEVDSLDS TDRGDAGYGS TGVGNWPSAL WEGFSSGDLK ESFV
//
