ID H9Z8N2_MACMU Unreviewed; 1178 AA.
AC H9Z8N2;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Integrin alpha-E {ECO:0000313|EMBL:AFH32298.1};
GN Name=ITGAE {ECO:0000313|EMBL:AFH32298.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:AFH32298.1};
RN [1] {ECO:0000313|EMBL:AFH32298.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Thymus {ECO:0000313|EMBL:AFH32298.1};
RX PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., Pandey S.,
RA Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., Tharp G.K.,
RA Marcais G., Roberts M., Ferguson B., Fox H.S., Treangen T., Salzberg S.L.,
RA Yorke J.A., Norgren R.B.Jr.;
RT "A new rhesus macaque assembly and annotation for next-generation
RT sequencing analyses.";
RL Biol. Direct 9:20-20(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; JU475494; AFH32298.1; -; mRNA.
DR AlphaFoldDB; H9Z8N2; -.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF79; INTEGRIN ALPHA-E; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 4.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 19..1178
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5001424977"
FT TRANSMEM 1126..1146
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT DOMAIN 202..382
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 499..559
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 562..626
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 630..690
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REGION 158..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..200
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1178 AA; 129876 MW; DFF666619CED4D2C CRC64;
MWLVHTLLCM ASLAPLAAFN VDVARPWLTP KGGAPFVLSS LLHQDPGTNH TWLLVTSPRT
ERTPVPLHRC SLVQDEILCH SVEHVPIPKG RHRGVTVARS HHGVLICIQV LARRPYSLSS
EFTGTCGLLG PDLRPQAQAN FFDLENLLDP DARVDTGDCY SNKEGSRGED VNTARRRRAL
EKEEEEEDEE EEEDEEEEAG TEIAIILDGS GSIDPPDFQR AKDFISNMMR NFYEKCFECN
FALVQYGGVI QTEFDLRDSQ DVMASLAKVQ NITQVGSVTK TASAMQHVLD NIFTSSHGSR
RKASKVMVVL TDGGIFEDPL DLTTVINSPK MHGVERFAIG VGEEFKSART ERELNLIASD
PDETHAFKVT NYMALDGLLS KLRYNIISME GTVGDALHYQ LAQIGFSAQI LDERQVLLGA
VGAFDWSGGA LLYNTRSRRG RFLNQTAAAV DGEAAQYSYL GYAVAVLHKT CSVSYVAGAP
RYKHHGAVFE LQKEGTETSF LPVLEGEQMG SYFGSELCPV DIDMDGTTDF LLVAAPFYHV
HGEEGRVYVY RLSEQDGSFS LARILSGHPG FASARFGFAM AAVGDISQDK LTDVAIGAPL
EGFGAGDGAS FGSVYIYNGH WDGLSAGPSQ RIRASAVAPG LQYFGMSVAG GFDISGDGLA
DITVGTLGRA VVFRSRPVVR LEVSMAFTPS ALPIGFNGVV NVRLCFEISS VATVSASGLR
GAFLNFTLDV DVGKERKRLQ CSDGRSCLGC LREWSSGSRL CEDLLLVPTE GELHEEDCFS
NATVKVGYQL QTPEGQTDHP QPILDRYAET FAIFQLPYEK ACKNKLFCVA ELQLATTVSQ
QELVVGLTKE LTLNISLTNS GEDSYMTSMA LNYPRNLQFK RMQKPPSPNI QCDDPQPAAS
VLVMTCRIGH PVLRRSSAHV SVVWQLEENA FPNRTADITV TVTNSNERRS VAEETHTLQF
RHGFVAVLSK PSIMYVHTGQ VLSHHKEFVF HIHGENLFGA EYQLRICVPT KLRGLQIVTV
KNLTRTQAFT VCTWSQERAC GFIPVQHVEE WHSVSCVIAS DKENVTVAAE ISVDHSEELL
KDVTELQILG EISFNKSLYE GLNAENHRTK ITVVFLKDEK YHSLPVIIKG SIGGLLVLIV
ILVILFKCGF FKRKYQQLNL ENIRKAQLKS ETLLEEEN
//
