ID H9ZFZ2_MACMU Unreviewed; 1055 AA.
AC H9ZFZ2;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Pleckstrin homology domain-containing family M member 1 {ECO:0000313|EMBL:AFH34858.1};
GN Name=PLEKHM1 {ECO:0000313|EMBL:AFH34858.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:AFH34858.1};
RN [1] {ECO:0000313|EMBL:AFH34858.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Thymus {ECO:0000313|EMBL:AFH34858.1};
RX PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., Pandey S.,
RA Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., Tharp G.K.,
RA Marcais G., Roberts M., Ferguson B., Fox H.S., Treangen T., Salzberg S.L.,
RA Yorke J.A., Norgren R.B.Jr.;
RT "A new rhesus macaque assembly and annotation for next-generation
RT sequencing analyses.";
RL Biol. Direct 9:20-20(2014).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JU478054; AFH34858.1; -; mRNA.
DR AlphaFoldDB; H9ZFZ2; -.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR CDD; cd13321; PH_PLEKHM1; 1.
DR CDD; cd17679; RUN_PLEKHM1; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR042827; PLEKHM1_PH.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047326; RUN_PLEKHM1.
DR PANTHER; PTHR12326; PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12326:SF5; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 2: Evidence at transcript level;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 40..182
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 533..624
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 985..1039
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 214..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1055 AA; 117429 MW; 740A0B02B1D68A5B CRC64;
MLSVENGLDP QAAIPVIKKK LVGSVKALQK QYVSLDTVVT SEDGDANTMC SALEAVFIHG
LHAKHIRAEA GGKRKKSAHQ KPLPQPVFWP LLKAVTHKHI ISELEHLTFV NTDVGRCRAW
LRLALNDGLM ECYLKLLLQE QARLREYYQP TALLRDAEEG EFLLSFLQGL TSLSFELSYK
SAILNEWTLT PLALSGLCPL SELDPLSTSG AELQRKESLD SISHSSGSED IEVHHSGHKI
RRNQKLTASS LSLDTASSSQ LSCSLNSDSC LLQENGSKSP DHCEEPMSYD SDLGTANAED
SDRSLQEVLL EFSKAQVNSV PTNGLSQETE SPTPQALLSL HGLNTSRHLH YEAPAEPLPA
QAASGTQDGV HMQEPHPRAP SALDLQQRVE STSGQQPSST VSKTAREVGQ GNGPQKAQAH
DGAGLKLVVS SPTSPKNKSW ISEDDFYRPS QEQPLEIASD HPIASSRGTP ESRPGLHRHF
SQGPRKSCSL GALDQACVPS PGRRQAQAAP SQGHKSFRVV HRRQMGLSNP FRGLMKLGTV
ERRGAMGIWK ELFCELSPLE FRLYLSNEER TCVENCSLLR CESVGPAHSD GRFELVFSGK
KLALRASSQD EAEDWLDRVR EALQKVRPQQ EDEWVNVQYP DQPEDPPEAP QGCPSPSDLL
SEPTALQGTQ FDWSSAQVPE PDAIKESLLY LYMDRTWMPY IFSLSLEALK CFRIRNNEKM
LSDSHGVETI RDILPDTSLG GPSFFKIITA KAVLKLQAGN AEEAALWRDL VRKVLASYLE
TAEEAVTLGG SLDENCQEVL KFATRENGFL LQYLVAIPME KGLDSQGCFC AGCSRQIGFS
FVRPKLCAFS GLYYCDICHQ DDASVIPARI IHNWDLTKRP ICRQALKFLT QIRVQPLINL
QMVNASLYEH VERMHLIGRS REQLKLLGDY LGLCRSGALK ELSKRLNHRD YLLESPHRFS
VADLQQIADG VYEGFLKALI EFASQHAYHC DLCTQRGFIC QICRHHDIIF PFEFDTTVRC
AECKTVFHQS CQAVVKKGCP RCARRRKYQE QNVFA
//
