ID H9ZT94_THETH Unreviewed; 344 AA.
AC H9ZT94;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Theronine dehydrogenase-like Zn-dependent dehydrogenase {ECO:0000313|EMBL:AFH39554.1};
GN ORFNames=TtJL18_1681 {ECO:0000313|EMBL:AFH39554.1};
OS Thermus thermophilus JL-18.
OC Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=798128 {ECO:0000313|EMBL:AFH39554.1, ECO:0000313|Proteomes:UP000007388};
RN [1] {ECO:0000313|EMBL:AFH39554.1, ECO:0000313|Proteomes:UP000007388}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JL-18 {ECO:0000313|EMBL:AFH39554.1,
RC ECO:0000313|Proteomes:UP000007388};
RX PubMed=23405355; DOI=10.1128/genomeA.00106-12;
RA Murugapiran S.K., Huntemann M., Wei C.L., Han J., Detter J.C., Han C.S.,
RA Erkkila T.H., Teshima H., Chen A., Kyrpides N., Mavrommatis K.,
RA Markowitz V., Szeto E., Ivanova N., Pagani I., Lam J., McDonald A.I.,
RA Dodsworth J.A., Pati A., Goodwin L., Peters L., Pitluck S., Woyke T.,
RA Hedlund B.P.;
RT "Whole Genome Sequencing of Thermus oshimai JL-2 and Thermus thermophilus
RT JL-18, Incomplete Denitrifiers from the United States Great Basin.";
RL Genome Announc. 1:E00106-E00112(2013).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CP003252; AFH39554.1; -; Genomic_DNA.
DR RefSeq; WP_011172490.1; NC_017587.1.
DR AlphaFoldDB; H9ZT94; -.
DR STRING; 798128.TtJL18_1681; -.
DR GeneID; 3168639; -.
DR KEGG; ttl:TtJL18_1681; -.
DR PATRIC; fig|798128.4.peg.1631; -.
DR HOGENOM; CLU_026673_11_3_0; -.
DR Proteomes; UP000007388; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08284; FDH_like_2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 8..342
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 344 AA; 36236 MW; 7376690DA2232167 CRC64;
MRAVVYKGPF QVAVEEVPEP RLEADTDALL EVELSAICGS DLHIYHGKIA GVLPGTVLGH
EFVGRIVEKG PLVPFPVGER VVGSFQVACG ECPACRKGQF FACSRGGVFG FGLALGNLPG
AQAERVRVPF ARHTLFPIGD LPAEEAILAG DILTTAYGGV RPFLTPGMSV AVVGSGPVGL
MAQMVAHALG AGQVYAIDPE EARLEKAKAL GSLPIHPKAE DPVARVRRET EGLGADLVVE
AVGGDGEALK LALRLAGPGG VVSSLGVPTA ERLDYPWLPA FSRGITLRSA LANVPRWIGE
VLALQKAGRL KGSFVFSHRL PLEEAPEGYR LFHERKATKV ALVP
//
