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Database: UniProt
Entry: HDA_PECAS
LinkDB: HDA_PECAS
Original site: HDA_PECAS 
ID   HDA_PECAS               Reviewed;         238 AA.
AC   Q6D7R8;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   07-JUN-2017, entry version 80.
DE   RecName: Full=DnaA regulatory inactivator Hda {ECO:0000255|HAMAP-Rule:MF_01158};
GN   Name=hda {ECO:0000255|HAMAP-Rule:MF_01158}; OrderedLocusNames=ECA1257;
OS   Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia
OS   carotovora subsp. atroseptica).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=218491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCRI 1043 / ATCC BAA-672;
RX   PubMed=15263089; DOI=10.1073/pnas.0402424101;
RA   Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J.,
RA   Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K.,
RA   Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J.,
RA   Fraser A., Hance Z., Hauser H., Jagels K., Moule S., Norbertczak H.,
RA   Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S.,
RA   Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K.;
RT   "Genome sequence of the enterobacterial phytopathogen Erwinia
RT   carotovora subsp. atroseptica and characterization of virulence
RT   factors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004).
CC   -!- FUNCTION: Mediates the interaction of DNA replication initiator
CC       protein DnaA with DNA polymerase subunit beta sliding clamp
CC       (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering
CC       DnaA inactive for reinitiation, a process called regulatory
CC       inhibition of DnaA or RIDA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms
CC       the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA,
CC       ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).
CC       {ECO:0000255|HAMAP-Rule:MF_01158}.
CC   -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01158}.
DR   EMBL; BX950851; CAG74167.1; -; Genomic_DNA.
DR   ProteinModelPortal; Q6D7R8; -.
DR   SMR; Q6D7R8; -.
DR   STRING; 218491.ECA1257; -.
DR   EnsemblBacteria; CAG74167; CAG74167; ECA1257.
DR   KEGG; eca:ECA1257; -.
DR   eggNOG; ENOG4108KZ1; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000256538; -.
DR   KO; K10763; -.
DR   OMA; DWGQIYR; -.
DR   OrthoDB; POG091H0GIW; -.
DR   Proteomes; UP000007966; Chromosome.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0032297; P:negative regulation of DNA-dependent DNA replication initiation; IEA:InterPro.
DR   HAMAP; MF_01158; Hda; 1.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR017788; Hda.
DR   InterPro; IPR022864; Hda_Enterobact.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   PRINTS; PR00051; DNAA.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE   3: Inferred from homology;
KW   Complete proteome; DNA replication; DNA replication inhibitor;
KW   Reference proteome.
FT   CHAIN         1    238       DnaA regulatory inactivator Hda.
FT                                /FTId=PRO_0000114317.
SQ   SEQUENCE   238 AA;  27092 MW;  D31C278F4268B2EB CRC64;
     MLEVILNTPA QLSLPLYLPD DETFASFYPG ENASLLAAVN NALYQEHGSY IYFWSREGGG
     RSHLLHAACA ELSRQERAVG YVPLDKRAYF VPDVLEGMEQ LALVCIDNIE SIAGDEAWEM
     AVFNLYNRIQ ETGRALLLIT GDRPPRQLNI RLPDLASRLD WGQIYKLQPL SDDEKGEALQ
     LRARLRGFEL PEDVSRFLLK RLDREMRTLF MTLDQLDHAS ITAQRKLTIP FVKEILGL
//
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