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Database: UniProt
Entry: HDA_SALAR
LinkDB: HDA_SALAR
Original site: HDA_SALAR 
ID   HDA_SALAR               Reviewed;         241 AA.
AC   A9MHP3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   07-JUN-2017, entry version 60.
DE   RecName: Full=DnaA regulatory inactivator Hda {ECO:0000255|HAMAP-Rule:MF_01158};
GN   Name=hda {ECO:0000255|HAMAP-Rule:MF_01158};
GN   OrderedLocusNames=SARI_00384;
OS   Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=41514;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-731 / CDC346-86 / RSK2980;
RG   The Salmonella enterica serovar Arizonae Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA   Fulton R., Chunyan W., Wollam A., Shah N., Pepin K., Bhonagiri V.,
RA   Nash W., Johnson M., Thiruvilangam P., Wilson R.;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the interaction of DNA replication initiator
CC       protein DnaA with DNA polymerase subunit beta sliding clamp
CC       (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering
CC       DnaA inactive for reinitiation, a process called regulatory
CC       inhibition of DnaA or RIDA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms
CC       the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA,
CC       ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).
CC       {ECO:0000255|HAMAP-Rule:MF_01158}.
CC   -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01158}.
DR   EMBL; CP000880; ABX20321.1; -; Genomic_DNA.
DR   RefSeq; WP_001192386.1; NC_010067.1.
DR   ProteinModelPortal; A9MHP3; -.
DR   SMR; A9MHP3; -.
DR   STRING; 882884.SARI_00384; -.
DR   EnsemblBacteria; ABX20321; ABX20321; SARI_00384.
DR   KEGG; ses:SARI_00384; -.
DR   eggNOG; ENOG4108KZ1; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000256538; -.
DR   KO; K10763; -.
DR   OMA; DWGQIYR; -.
DR   OrthoDB; POG091H0GIW; -.
DR   Proteomes; UP000002084; Chromosome.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0032297; P:negative regulation of DNA-dependent DNA replication initiation; IEA:InterPro.
DR   HAMAP; MF_01158; Hda; 1.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR017788; Hda.
DR   InterPro; IPR022864; Hda_Enterobact.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   PRINTS; PR00051; DNAA.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE   3: Inferred from homology;
KW   Complete proteome; DNA replication; DNA replication inhibitor;
KW   Reference proteome.
FT   CHAIN         1    241       DnaA regulatory inactivator Hda.
FT                                /FTId=PRO_1000085355.
SQ   SEQUENCE   241 AA;  27513 MW;  BC43A160C971CB88 CRC64;
     MQSWVEVSLN TPAQLSLPLY LPDDETFASF WPGDNASLLA ALQNVLRQEH SGYIYLWARE
     GAGRSHLLHA ACAELSQRGD AVGYVPLDKR TWFVPEVLDG MEHLSLVCID NIECVAGDEL
     WEMAIFDLYN RILESGKTRL LITGDRPPRQ LNLGLPDLAS RLDWGQIYKL QPLSDEDKLQ
     ALQLRARLRG FELPEDVGRF LLKRLDREMR TLFMTLDQLD HASITAQRKL TIPFVKEILK
     L
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