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Database: UniProt
Entry: HDA_YERPE
LinkDB: HDA_YERPE
Original site: HDA_YERPE 
ID   HDA_YERPE               Reviewed;         239 AA.
AC   Q8ZCC1; Q0WCJ7; Q74SC4; Q7CJJ7;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   05-JUL-2017, entry version 91.
DE   RecName: Full=DnaA regulatory inactivator Hda {ECO:0000255|HAMAP-Rule:MF_01158};
GN   Name=hda {ECO:0000255|HAMAP-Rule:MF_01158}; Synonyms=dnaA1;
GN   OrderedLocusNames=YPO3071, y1410, YP_2693;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G.,
RA   Feltwell T., Hamlin N., Holroyd S., Jagels K., Karlyshev A.V.,
RA   Leather S., Moule S., Oyston P.C.F., Quail M.A., Rutherford K.M.,
RA   Simmonds M., Skelton J., Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/JB.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C.,
RA   Fetherston J.D., Lindler L.E., Brubaker R.R., Plano G.V.,
RA   Straley S.C., McDonough K.A., Nilles M.L., Matson J.S., Blattner F.R.,
RA   Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z.,
RA   Jin L., Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J.,
RA   Yang H., Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Mediates the interaction of DNA replication initiator
CC       protein DnaA with DNA polymerase subunit beta sliding clamp
CC       (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering
CC       DnaA inactive for reinitiation, a process called regulatory
CC       inhibition of DnaA or RIDA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms
CC       the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA,
CC       ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).
CC       {ECO:0000255|HAMAP-Rule:MF_01158}.
CC   -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01158}.
DR   EMBL; AL590842; CAL21673.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM84982.1; -; Genomic_DNA.
DR   EMBL; AE017042; AAS62883.1; -; Genomic_DNA.
DR   PIR; AF0373; AF0373.
DR   RefSeq; WP_002208566.1; NZ_LT605018.1.
DR   RefSeq; YP_002347991.1; NC_003143.1.
DR   ProteinModelPortal; Q8ZCC1; -.
DR   SMR; Q8ZCC1; -.
DR   STRING; 187410.y1410; -.
DR   DNASU; 1146357; -.
DR   EnsemblBacteria; AAM84982; AAM84982; y1410.
DR   EnsemblBacteria; AAS62883; AAS62883; YP_2693.
DR   GeneID; 1175892; -.
DR   KEGG; ype:YPO3071; -.
DR   KEGG; ypk:y1410; -.
DR   KEGG; ypm:YP_2693; -.
DR   PATRIC; fig|1028802.3.peg.1589; -.
DR   eggNOG; ENOG4108KZ1; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000256538; -.
DR   KO; K10763; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0032297; P:negative regulation of DNA-dependent DNA replication initiation; IBA:GO_Central.
DR   HAMAP; MF_01158; Hda; 1.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR017788; Hda.
DR   InterPro; IPR022864; Hda_Enterobact.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   PRINTS; PR00051; DNAA.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE   3: Inferred from homology;
KW   Complete proteome; DNA replication; DNA replication inhibitor;
KW   Reference proteome.
FT   CHAIN         1    239       DnaA regulatory inactivator Hda.
FT                                /FTId=PRO_0000114322.
SQ   SEQUENCE   239 AA;  27143 MW;  C1D2C204352E4498 CRC64;
     MLVEVLLNTP AQLSLPLYLP DDETFASFYP GENPSLLAAI QSAVHQPHGS YIYFWSREGG
     GRSHLLHAAC AELSQQGEAV GYVPLDKRAY FIPEVLEGME QLALVCIDNI ECIAGDEQWE
     MAMFNLYNRI VETGRTRLLI TGDRPPRQLN LGLPDLASRL DWGQIYKLQP LSDDEKLQAL
     QLRAKLRGFE LPEDVGRFLL KRLDREMRTL FMTLDQLDRA SITAQRKLTI PFVKEILSL
//
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