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Database: UniProt
Entry: HEAT1_DICDI
LinkDB: HEAT1_DICDI
Original site: HEAT1_DICDI 
ID   HEAT1_DICDI             Reviewed;        2237 AA.
AC   Q54ML4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   27-MAR-2024, entry version 111.
DE   RecName: Full=HEAT repeat-containing protein 1 homolog;
GN   Name=heatr1; ORFNames=DDB_G0285875;
OS   Dictyostelium discoideum (Social amoeba).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Ribosome biogenesis factor. Involved in nucleolar processing
CC       of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA
CC       transcription by RNA polymerase I. Part of the small subunit (SSU)
CC       processome, first precursor of the small eukaryotic ribosomal subunit.
CC       During the assembly of the SSU processome in the nucleolus, many
CC       ribosome biogenesis factors, an RNA chaperone and ribosomal proteins
CC       associate with the nascent pre-rRNA and work in concert to generate RNA
CC       folding, modifications, rearrangements and cleavage as well as targeted
CC       degradation of pre-ribosomal RNA by the RNA exosome.
CC       {ECO:0000250|UniProtKB:Q9H583}.
CC   -!- SUBUNIT: Part of the small subunit (SSU) processome, composed of more
CC       than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
CC       {ECO:0000250|UniProtKB:Q9H583}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9H583}.
CC   -!- SIMILARITY: Belongs to the HEATR1/UTP10 family. {ECO:0000305}.
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DR   EMBL; AAFI02000082; EAL64472.1; -; Genomic_DNA.
DR   RefSeq; XP_637976.1; XM_632884.1.
DR   AlphaFoldDB; Q54ML4; -.
DR   SMR; Q54ML4; -.
DR   STRING; 44689.Q54ML4; -.
DR   PaxDb; 44689-DDB0237545; -.
DR   EnsemblProtists; EAL64472; EAL64472; DDB_G0285875.
DR   GeneID; 8625328; -.
DR   KEGG; ddi:DDB_G0285875; -.
DR   dictyBase; DDB_G0285875; -.
DR   eggNOG; KOG1837; Eukaryota.
DR   HOGENOM; CLU_001128_3_0_1; -.
DR   InParanoid; Q54ML4; -.
DR   OMA; CATQIDS; -.
DR   PhylomeDB; Q54ML4; -.
DR   Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q54ML4; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; ISS:UniProtKB.
DR   GO; GO:0034455; C:t-UTP complex; IBA:GO_Central.
DR   GO; GO:0030515; F:snoRNA binding; ISS:dictyBase.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR   GO; GO:0042274; P:ribosomal small subunit biogenesis; ISS:UniProtKB.
DR   GO; GO:0006364; P:rRNA processing; ISS:dictyBase.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012954; BP28_C_dom.
DR   InterPro; IPR022125; U3snoRNP10_N.
DR   InterPro; IPR040191; UTP10.
DR   PANTHER; PTHR13457; BAP28; 1.
DR   PANTHER; PTHR13457:SF1; HEAT REPEAT-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF08146; BP28CT; 1.
DR   Pfam; PF12397; U3snoRNP10; 1.
DR   SMART; SM01036; BP28CT; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosome biogenesis; rRNA processing; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..2237
FT                   /note="HEAT repeat-containing protein 1 homolog"
FT                   /id="PRO_0000330922"
FT   REPEAT          224..262
FT                   /note="HEAT 1"
FT   REPEAT          858..895
FT                   /note="HEAT 2"
FT   REPEAT          1586..1624
FT                   /note="HEAT 3"
FT   REPEAT          1674..1712
FT                   /note="HEAT 4"
FT   REPEAT          1715..1761
FT                   /note="HEAT 5"
FT   REPEAT          1767..1805
FT                   /note="HEAT 6"
FT   REPEAT          2104..2142
FT                   /note="HEAT 7"
FT   REPEAT          2191..2229
FT                   /note="HEAT 8"
FT   REGION          962..981
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1920..1960
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2031..2073
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2237 AA;  254183 MW;  7B110BFB11709984 CRC64;
     MTTSLDKQLL QVKEKIHYVD VSKKRDSLLF GAVEAANIDL DSVLAMGQEG LSELINIDSR
     FKCFQLTLFS DNSKSFNRVL ENKEENNKID IEINKFLELQ SNYFLLSSAH KSLEWLIRRY
     RINEFNIDSI ISSIIPYHES NIFAKFLSIL RFEFNKKWQF LTGVQENKVY IPREYFIGVV
     GSHPFFLEFI YSTIENYDKK DVMSKPLISF FTAFLIELLS ANTTSYIRDT LSCLTKCLKS
     KNSDLQLSSY MILSIIASKV TLSKDVIELL FKTTLKHCTN NFSQAFTFLM VLFQKQKFDS
     LPNETLKTLV SIPALFEILL DFNSQEKSLD RVLLILFKYL SKSCIESAES YTLLSQLIEE
     LVPISNQYHV LIFNTLTKSY LATTKNSSKD EVDESVINIL RSLNSEVVQD EFKKLSNNNN
     NNNNNNNNKQ KLNEIIKLQK SVLQQKTITT SSSNTIFLKL QSNIPSERKE GLTLFKKEYC
     SKTGKEKEET TTSTDFNSIS KSFSSTIYQR LIDSDGSIVK EAWNLPSLNL IVSPKELLKA
     SIEFFKVQSF LNDKKLLDTV LSTITSVVVN QSSNSSLTPD FVSILLPQLL DISTTTTTTA
     TSIIKKLNKD IHPIFNNITS SNIESLIKSI STNLDKESNI TFINQISKST FSTFKSDIFI
     ILILLNSIIS CNNNNNNKKN NNNLIYQMFN IIVEISKSYL SKEESIITNI NNLQEVYKII
     NENNNNNFNL KQQISLICSL LSIAIDSLFT ISPEQFMKQL QNSSLSSSSN TIEEKMIKEI
     QNICKLIFNS KITNIDLVLR SIVKKFFGNQ LVFFKFLSQF WEVNENSENQ DITTIYQSLC
     LSGILVNSKS FNRYLINNNQ AVALIPYLLL LKNQDSSIRS TSLDSIQEIY KQIKSSSIEA
     SSSTTTSNRL NFYTSNQPTI ELKVLIKFLA QLVQYKNEIT MDKTFLDSYF SKVLFNSQIS
     SSSKASSSSD DDDDDDDDVD QDVSKMTKQD IELIGKFLIS SSLLIESLSS RLTMLQSLQS
     IKDDVTFVEV TINYISQLLE NVKNATLTYD ESLILDILLK RLGQTSVLTN PKTKKQSLSL
     FISSLSISNE LDLTIAGGGN DKPIKYTPLV ALIGSINKSL LLTVPVKEQI GIVETVLSYF
     FSESNQIKQL AKNTLLSVLV DATVILPMLL PEKQPQQQQQ STTSLPIPRY NSLFELIRLN
     SSKINGISIL VTPILSIIKK METSIVENVE KDALEYCKQL AMASLGSIID CSSVKDVKSL
     ETSFDISIII KCVESSNNLQ TCSSALILLS NMASKFPQKL FKFMESIIKM IKFVLTNGDD
     NFSFMILERF LIQLLPSLVK QGISLVQIFK LFLDSFSSIP KKFRLQLFNC ICQSVAYKQL
     HILFSLILTK KIQDLRIITN KLKHLDKDTI MSSDEQIKEE IDYEQFNEFI SQFSDQIPVL
     EMSTSLGSLC QSINLISIES GNCVEALSEE EEEICSLLSR NNSKDNRLLQ ANTLDFICER
     LSSKLYLDSF SFDLTSQQKE LVETKYLGAF ENLLILLKKT TEYSEKTSNI KLNGSANSIS
     IASGKDKFIK KLLSSINLCM DRYGQLLSVK GFISTITQLL NHSDSNVRRR SLVIFNEKIT
     LVKDDLTQDQ VNQFLSLIDS FTRIIDSQNE TETNKQTSLL SFEILARNFS TTNATAFLSQ
     IPIIIKSMGH SSHQVVSSSL ICIATLCCEL QAKTIPYIPQ FFPVLLNTLT GSYKTNVEEE
     NETRTLLQIS CISSLEMMLN TISKFLSPYL PQLLNALLHP RLTSNSMLSG KLFAQVKRLL
     NILTKNVEFR LLLPAMFSAY EFAVQSENDL SLICLFDFVG DISANLGPKD IALHHKSIFK
     FYLQCFEFRK KYKNRVKNAD KVEDHIISSF MTLVMKLNEN LFKPLFIKVL DWALNIQNGQ
     QNGKHTDDDD EENGSDDEES DEDKPKKKKL VNGKSKSTKT QPEISKDNLL FFYKIVNSLA
     SNLKTIFVPY FGYFFDDSIR QLQNIYSNIP FSQQPQQQPQ QPTVNDNTTI TLLNNNNNNN
     NNNINNKRKK NQNITNTTTT NNNSNNNLNN SNNNNIDQDE SILCFVISAL EKCFMYDTDG
     FLDKQKFEQI LPALVNQLDN QMGTVESYKL RVSRYIAPTI TQLAVVINQD LLWKHLNHTV
     LMKTRSPYSI VRYSSMVVVQ SLHKKMGEQL LILLPETIPF ISELLEDSVP EVEQITQDVV
     KIIETHLGAE ESISSYL
//
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