ID HEXR_PSEAE Reviewed; 285 AA.
AC O68281; Q9HZ53;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2001, sequence version 2.
DT 27-MAR-2024, entry version 134.
DE RecName: Full=HTH-type transcriptional regulator HexR {ECO:0000305};
DE AltName: Full=Hex regulon repressor {ECO:0000312|EMBL:AAC38310.1};
GN Name=hexR {ECO:0000312|EMBL:AAC38310.1};
GN OrderedLocusNames=PA3184 {ECO:0000312|EMBL:AAG06572.1};
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RA Hager P.W., Dail M.B., Phibbs P.V. Jr.;
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Involved in regulation of glucose metabolism. Transcriptional
CC repressor of the gap-1 gene and of the edd-glk-gltR-2 and zwf-pgl-eda
CC operons. Acts by binding directly to an inverted pseudopalindromic
CC sequence in the promoter region. {ECO:0000250|UniProtKB:Q88P32}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF029673; AAC38310.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG06572.1; -; Genomic_DNA.
DR PIR; B83248; B83248.
DR RefSeq; NP_251874.1; NC_002516.2.
DR RefSeq; WP_003091466.1; NZ_QZGE01000023.1.
DR AlphaFoldDB; O68281; -.
DR SMR; O68281; -.
DR STRING; 208964.PA3184; -.
DR PaxDb; 208964-PA3184; -.
DR GeneID; 882618; -.
DR KEGG; pae:PA3184; -.
DR PATRIC; fig|208964.12.peg.3328; -.
DR PseudoCAP; PA3184; -.
DR HOGENOM; CLU_055769_0_0_6; -.
DR InParanoid; O68281; -.
DR OrthoDB; 257751at2; -.
DR PhylomeDB; O68281; -.
DR BioCyc; PAER208964:G1FZ6-3244-MONOMER; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd05013; SIS_RpiR; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR000281; HTH_RpiR.
DR InterPro; IPR047640; RpiR-like.
DR InterPro; IPR035472; RpiR-like_SIS.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR30514; GLUCOKINASE; 1.
DR PANTHER; PTHR30514:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATOR HEXR-RELATED; 1.
DR Pfam; PF01418; HTH_6; 1.
DR Pfam; PF01380; SIS; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51071; HTH_RPIR; 1.
DR PROSITE; PS51464; SIS; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..285
FT /note="HTH-type transcriptional regulator HexR"
FT /id="PRO_0000068624"
FT DOMAIN 2..78
FT /note="HTH rpiR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00390"
FT DOMAIN 122..261
FT /note="SIS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00797"
FT DNA_BIND 38..57
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00390"
FT CONFLICT 104
FT /note="I -> F (in Ref. 1; AAC38310)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 285 AA; 31170 MW; 0EF1A86101F2C7BC CRC64;
MKNLLEQIQS RLDELNKAER KVAEVILQNP QQATRFSIAA LAQAAAVSEP TVNRFCRSFG
MSGYPELKIQ LAQSLASGAA FVTQAVAEDD GPEAYTRKIF SNTIASLDSA HKLLDPRVID
RAVDLLIQAR QIHFFGLGAS ASVALDAQHK FFRFNLAVSA QADVLMQRMI ASVAHTGDLF
VVISYTGRTR ELVEVAHLAR ENGASVLGLT AAGSPLARAS TLCLDIPLPE DTDIYMPMTS
RIVQLTVLDV LATGVTLRRG VDFQPHLRRI KESLVPTRYP LDEDN
//
