ID HMGL_TRYBR Reviewed; 271 AA.
AC P26586;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=High mobility group protein homolog TDP-1;
OS Trypanosoma brucei rhodesiense.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=31286;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=WRATat 1.1;
RX PubMed=1565127; DOI=10.1016/0166-6851(92)90206-y;
RA Erondu N.E., Donelson J.E.;
RT "Differential expression of two mRNAs from a single gene encoding an HMG1-
RT like DNA binding protein of African trypanosomes.";
RL Mol. Biochem. Parasitol. 51:111-118(1992).
CC -!- FUNCTION: Unknown. May play a role in transcription and/or DNA
CC replication. It is not known whether this protein is DNA sequence
CC binding-specific or not.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR EMBL; M74017; AAA73081.1; -; mRNA.
DR PIR; A45606; A45606.
DR AlphaFoldDB; P26586; -.
DR SMR; P26586; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.30.10; High mobility group box domain; 2.
DR InterPro; IPR014876; DEK_C.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR48112; HIGH MOBILITY GROUP PROTEIN DSP1; 1.
DR PANTHER; PTHR48112:SF32; HIGH MOBILITY GROUP PROTEIN DSP1; 1.
DR Pfam; PF08766; DEK_C; 1.
DR Pfam; PF00505; HMG_box; 2.
DR PRINTS; PR00886; HIGHMOBLTY12.
DR SMART; SM00398; HMG; 2.
DR SUPFAM; SSF47095; HMG-box; 2.
DR PROSITE; PS51998; DEK_C; 1.
DR PROSITE; PS50118; HMG_BOX_2; 2.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Repeat.
FT CHAIN 1..271
FT /note="High mobility group protein homolog TDP-1"
FT /id="PRO_0000048563"
FT DOMAIN 8..63
FT /note="DEK-C"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01342"
FT DNA_BIND 118..186
FT /note="HMG box 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT DNA_BIND 206..270
FT /note="HMG box 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 75..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 271 AA; 30866 MW; 0B2ED4B7317A5802 CRC64;
MATELKKGPL PTDIEETVIT IMREEGVRYI TAKILRMRLE SKYQMEFGPH KAAIDDIVAR
AMQRPEFKKQ LELALKEKDA SKSSGGKGSK RARSAGAEAP SKTKKEMTEK PKKPADYPKP
AVSSYLLFVA DQREELKAKN PGMQNTAILQ TLGKMWSDAS DDVKEHYRKK AEEDKARFRR
EVDEYKRQGG KEYGRGGKIK KDSNAPKRAM TSFMFFSSDF RSKHSDLSIV EMSKAAGAAW
KELGPEERKV YEEMAEKDKE RYKREMAALP K
//
