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Database: UniProt
Entry: HNF1B_PIG
LinkDB: HNF1B_PIG
Original site: HNF1B_PIG 
ID   HNF1B_PIG               Reviewed;         559 AA.
AC   Q03365;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   01-OCT-2014, entry version 98.
DE   RecName: Full=Hepatocyte nuclear factor 1-beta;
DE            Short=HNF-1-beta;
DE            Short=HNF-1B;
DE   AltName: Full=FPC-binding protein;
DE            Short=FPCB;
DE   AltName: Full=Transcription factor 2;
DE            Short=TCF-2;
GN   Name=HNF1B; Synonyms=TCF2;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Kidney;
RX   PubMed=8388098; DOI=10.1093/nar/21.8.1845;
RA   Menoud P.-A., Matthies R., Hofsteenge J., Nagamine Y.;
RT   "Purification and cDNA cloning of a transcription factor which
RT   functionally cooperates within a cAMP regulatory unit in the porcine
RT   uPA gene.";
RL   Nucleic Acids Res. 21:1845-1852(1993).
CC   -!- FUNCTION: Transcription factor, probably binds to the inverted
CC       palindrome 5'-GTTAATNATTAAC-3'. Binds to the PFC element in the
CC       UPA gene.
CC   -!- SUBUNIT: Binds DNA as a dimer. Can form homodimer or heterodimer
CC       with HNF1-alpha.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the HNF1 homeobox family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 homeobox DNA-binding domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR   EMBL; X69675; CAA49356.1; -; mRNA.
DR   PIR; S33724; S33724.
DR   RefSeq; NP_999121.1; NM_213956.1.
DR   UniGene; Ssc.16447; -.
DR   ProteinModelPortal; Q03365; -.
DR   SMR; Q03365; 1-30, 91-307.
DR   GeneID; 397002; -.
DR   KEGG; ssc:397002; -.
DR   CTD; 6928; -.
DR   HOVERGEN; HBG005980; -.
DR   KO; K08034; -.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0031018; P:endocrine pancreas development; ISS:UniProtKB.
DR   GO; GO:0048806; P:genitalia development; ISS:UniProtKB.
DR   GO; GO:0001822; P:kidney development; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.60; -; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR006899; HNF-1_N.
DR   InterPro; IPR023219; HNF1_dimer_dom.
DR   InterPro; IPR006897; HNF1b_C.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR009057; Homeodomain-like.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom.
DR   Pfam; PF04814; HNF-1_N; 1.
DR   Pfam; PF04812; HNF-1B_C; 1.
DR   Pfam; PF00046; Homeobox; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF100957; SSF100957; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   Activator; Complete proteome; Direct protein sequencing; DNA-binding;
KW   Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    559       Hepatocyte nuclear factor 1-beta.
FT                                /FTId=PRO_0000049123.
FT   DNA_BIND    231    312       Homeobox; HNF1-type.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00108}.
FT   REGION        1     31       Dimerization. {ECO:0000250}.
SQ   SEQUENCE   559 AA;  61528 MW;  0CF648543ADE2815 CRC64;
     MVSKLTSLQQ ELLSALLSSG VTKEVLVQAL EELLPSPSFG VKLETLPLSP GSGTEPDTKP
     VFHTLTNGHA KGRLSGDEGS EDGDDYDTPP ILKELQALNT EEAADDGAEV DRMLSEDPWR
     AAKMIKGYMQ QHNIPQREVV DVTGLNQSHL SQHLNKGTPM KTQKRAALYT WYVRKQREIL
     RQFNQTVQSS GNLTDKSSQD QLLFLFPEFS QQSQGPGQSD DACSEPTNKK MRRNRFKWGP
     ASQQILYQAY DRQKNPSKEE REALVEECNR AECLQRGVSP SKAHGLGSNL VTEVRVYNWF
     ANRRKEEEAF RQKLAMDAYS SNQTHSLNTL LSHSSPHHQP STSPPNKLPG VRYNQQGNNE
     VTSSSTISHH GNSAMVTSQS VLQQVSPASL DPGHNLLSPD GKMQISVSGG GLPPVSTLTN
     IHSLSHHNPQ QSQNLIMTPL SGVMAIAQSL NSSQAQSVPV INSVAGSLAA LQPVQFSQQL
     HSPHQQPLMQ QSPGSHMAQQ PFMAAVTQLQ NSHMYTHKQE PPQYSHTSRF PPAMVVTDTS
     SISTLTNMSS SKQCPLQAW
//
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