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Database: UniProt
Entry: HPR_BACC2
LinkDB: HPR_BACC2
Original site: HPR_BACC2 
ID   HPR_BACC2               Reviewed;         185 AA.
AC   B7IKC1;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   24-JAN-2024, entry version 83.
DE   RecName: Full=HTH-type transcriptional regulator Hpr {ECO:0000255|HAMAP-Rule:MF_01911};
DE   AltName: Full=Protease production regulatory protein Hpr {ECO:0000255|HAMAP-Rule:MF_01911};
GN   Name=hpr {ECO:0000255|HAMAP-Rule:MF_01911};
GN   OrderedLocusNames=BCG9842_B4223;
OS   Bacillus cereus (strain G9842).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=405531;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G9842;
RA   Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A.,
RA   Ravel J., Sutton G.;
RT   "Genome sequence of Bacillus cereus G9842.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of protease production and sporulation.
CC       {ECO:0000255|HAMAP-Rule:MF_01911}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01911}.
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DR   EMBL; CP001186; ACK96855.1; -; Genomic_DNA.
DR   RefSeq; WP_000834924.1; NC_011772.1.
DR   AlphaFoldDB; B7IKC1; -.
DR   SMR; B7IKC1; -.
DR   GeneID; 72447830; -.
DR   KEGG; bcg:BCG9842_B4223; -.
DR   HOGENOM; CLU_115790_0_0_9; -.
DR   OMA; EKDWQNW; -.
DR   Proteomes; UP000006744; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   HAMAP; MF_01911; HTH_type_Hpr; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023488; HTH_tscrpt_reg_Hpr.
DR   InterPro; IPR039422; MarR/SlyA-like.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR33164:SF58; HTH-TYPE TRANSCRIPTIONAL REGULATOR HPR; 1.
DR   PANTHER; PTHR33164; TRANSCRIPTIONAL REGULATOR, MARR FAMILY; 1.
DR   Pfam; PF01047; MarR; 1.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Sporulation; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..185
FT                   /note="HTH-type transcriptional regulator Hpr"
FT                   /id="PRO_1000188792"
FT   DOMAIN          13..157
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01911"
FT   DNA_BIND        63..86
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01911"
SQ   SEQUENCE   185 AA;  21730 MW;  C9F002F48E95F688 CRC64;
     MKSGEKDYSV KEAMIFSQRI AQLSKALWKC VEKDWQQWIK PYDLNINEHH ILTIAYHLKG
     ASISEIAKFG VMHVSTAFNF SKKLEERGYL VFSKKEDDKR NTYIEITDKG EELLLRLMEE
     YDPENNSVFN GALALRNFYG KFPENIELIA ILRNIYGQDF IDIFEKSLED IEENFTESDQ
     KLVKK
//
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