ID HXC4_ORYLA Reviewed; 261 AA.
AC Q9PVS4;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 24-JAN-2024, entry version 134.
DE RecName: Full=Homeobox protein Hox-C4;
GN Name=hoxc4; Synonyms=hoxc4a;
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kondo S., Naruse K., Shima A.;
RT "Hox genes of the medakafish Oryzias latipes.";
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC {ECO:0000305}.
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DR EMBL; AB026955; BAA86238.1; -; mRNA.
DR RefSeq; NP_001098348.1; NM_001104878.2.
DR RefSeq; XP_011475037.1; XM_011476735.1.
DR AlphaFoldDB; Q9PVS4; -.
DR SMR; Q9PVS4; -.
DR STRING; 8090.ENSORLP00000009978; -.
DR Ensembl; ENSORLT00000009979.3; ENSORLP00000009978.2; ENSORLG00000007955.3.
DR Ensembl; ENSORLT00015030554.1; ENSORLP00015021134.1; ENSORLG00015022346.1.
DR Ensembl; ENSORLT00020005669.1; ENSORLP00020024944.1; ENSORLG00020006629.1.
DR GeneID; 100125418; -.
DR KEGG; ola:100125418; -.
DR CTD; 30345; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000160794; -.
DR HOGENOM; CLU_061398_0_0_1; -.
DR InParanoid; Q9PVS4; -.
DR OMA; PACNQPN; -.
DR OrthoDB; 728401at2759; -.
DR TreeFam; TF352857; -.
DR Proteomes; UP000001038; Chromosome 7.
DR Proteomes; UP000265180; Chromosome 7.
DR Proteomes; UP000265200; Chromosome 7.
DR Bgee; ENSORLG00000007955; Expressed in sexually immature organism and 9 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45771:SF9; HOMEOBOX PROTEIN HOX-C4; 1.
DR PANTHER; PTHR45771; HOMEOTIC PROTEIN DEFORMED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..261
FT /note="Homeobox protein Hox-C4"
FT /id="PRO_0000200168"
FT DNA_BIND 154..213
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 85..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 133..138
FT /note="Antp-type hexapeptide"
FT COMPBIAS 94..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 261 AA; 29373 MW; 01890A19997E2B94 CRC64;
MIMSSYLMES NYIDPKFPPC EEYSQNNYIP DSPEYYSRAR DTGYQHHHQE LYPPRASYQE
RQYNCASIPE PDTPRGHGIP HSAHLLAGKG QPASCETPQL SMSPATPPAA ASACNQATPE
HPNSTASSKQ PVVYPWMKKI HVSTVNSGYN GTEPKRSRTA YTRQQVLELE KEFHYNRYLT
RRRRIEIAHT LVLSERQIKI WFQNRRMKWK KDHRLPNTKV RSSSSGSNTS SAAGGVAAAS
ATNSGPDELS GAQHGEDITR L
//
