ID HXC4_RAT Reviewed; 76 AA.
AC P18865;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 24-JAN-2024, entry version 137.
DE RecName: Full=Homeobox protein Hox-C4;
DE AltName: Full=Homeobox protein R3;
DE Flags: Fragment;
GN Name=Hoxc4; Synonyms=Hoxc-4;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=2907739; DOI=10.1242/dev.103.3.601;
RA Falzon M., Chung S.Y.;
RT "The expression of rat homeobox-containing genes is developmentally
RT regulated and tissue specific.";
RL Development 103:601-610(1988).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Predominantly spinal cord and kidney.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC {ECO:0000305}.
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DR EMBL; M37567; AAA41343.1; -; Genomic_DNA.
DR PIR; C43559; C43559.
DR AlphaFoldDB; P18865; -.
DR SMR; P18865; -.
DR STRING; 10116.ENSRNOP00000022398; -.
DR PhosphoSitePlus; P18865; -.
DR PaxDb; 10116-ENSRNOP00000022398; -.
DR UCSC; RGD:1586210; rat.
DR AGR; RGD:1586210; -.
DR RGD; 1586210; Hoxc4.
DR InParanoid; P18865; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0071837; F:HMG box domain binding; ISO:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR GO; GO:0051216; P:cartilage development; ISO:RGD.
DR GO; GO:1990792; P:cellular response to glial cell derived neurotrophic factor; IEP:RGD.
DR GO; GO:0048562; P:embryonic organ morphogenesis; ISO:RGD.
DR GO; GO:1904840; P:positive regulation of male germ-line stem cell asymmetric division; IMP:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0001501; P:skeletal system development; ISO:RGD.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45771:SF9; HOMEOBOX PROTEIN HOX-C4; 1.
DR PANTHER; PTHR45771; HOMEOTIC PROTEIN DEFORMED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN <1..76
FT /note="Homeobox protein Hox-C4"
FT /id="PRO_0000200166"
FT DNA_BIND 11..70
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT NON_TER 1
SQ SEQUENCE 76 AA; 9293 MW; 5235F665C0672385 CRC64;
LVVMLESRFP GPARGVANCR QQVLELEKEF HYNRYLTRRR RIEIAHSLCL SERQIKIWFQ
NRRMKWKKDH DSPTPK
//
