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Database: UniProt
Entry: HXD11_CHICK
LinkDB: HXD11_CHICK
Original site: HXD11_CHICK 
ID   HXD11_CHICK             Reviewed;         280 AA.
AC   P24342; Q90780;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 2.
DT   24-JAN-2024, entry version 144.
DE   RecName: Full=Homeobox protein Hox-D11;
DE   AltName: Full=Homeobox protein Hox-4.6;
DE            Short=Chox-4.6;
DE            Short=Ghox-4.6;
DE   AltName: Full=Homeobox protein Hox-4E;
DE            Short=Chox-4E;
GN   Name=HOXD11; Synonyms=CHOX-4.6;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1347239; DOI=10.1002/aja.1001930112;
RA   Rogina B., Coelho C.N., Kosher R.A., Upholt W.B.;
RT   "The pattern of expression of the chicken homolog of HOX1I in the
RT   developing limb suggests a possible role in the ectodermal inhibition of
RT   chondrogenesis.";
RL   Dev. Dyn. 193:92-101(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 181-280.
RA   Nohno T.;
RL   Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 208-268.
RX   PubMed=1672266; DOI=10.1016/0092-8674(91)90274-3;
RA   Nohno T., Noji S., Koyama E., Ohyama K., Myokai F., Kuroiwa A., Saito T.,
RA   Taniguchi S.;
RT   "Involvement of the Chox-4 chicken homeobox genes in determination of
RT   anteroposterior axial polarity during limb development.";
RL   Cell 64:1197-1205(1991).
RN   [4]
RP   NUCLEOTIDE SEQUENCE OF 208-267.
RX   PubMed=1673231; DOI=10.1038/350585a0;
RA   Izpisua-Belmonte J.-C., Tickle C., Dolle P., Wolpert L., Duboule D.;
RT   "Expression of the homeobox Hox-4 genes and the specification of position
RT   in chick wing development.";
RL   Nature 350:585-589(1991).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Coordinately expressed in partially overlapping
CC       domains during wing development.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR   EMBL; M81249; AAA48822.1; -; mRNA.
DR   EMBL; D10288; BAA01133.1; -; Genomic_DNA.
DR   PIR; B37914; B37914.
DR   RefSeq; NP_989951.1; NM_204620.1.
DR   AlphaFoldDB; P24342; -.
DR   SMR; P24342; -.
DR   STRING; 9031.ENSGALP00000046110; -.
DR   PaxDb; 9031-ENSGALP00000015069; -.
DR   GeneID; 395328; -.
DR   KEGG; gga:395328; -.
DR   CTD; 3237; -.
DR   VEuPathDB; HostDB:geneid_395328; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   HOGENOM; CLU_079662_0_0_1; -.
DR   InParanoid; P24342; -.
DR   OMA; CNFFTSV; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; P24342; -.
DR   PRO; PR:P24342; -.
DR   Proteomes; UP000000539; Chromosome 7.
DR   Bgee; ENSGALG00000039629; Expressed in colon and 4 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR021918; DUF3528.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR46092; HOMEOBOX PROTEIN HOX-A11-RELATED; 1.
DR   PANTHER; PTHR46092:SF2; HOMEOBOX PROTEIN HOX-D11; 1.
DR   Pfam; PF12045; DUF3528; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..280
FT                   /note="Homeobox protein Hox-D11"
FT                   /id="PRO_0000200233"
FT   DNA_BIND        208..267
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          135..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        170..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        181..200
FT                   /note="VTTASGAASPPGEAVAEKSN -> SSSQPSAVVFCINQHFLSLI (in
FT                   Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   280 AA;  31923 MW;  8E0877450FD4B922 CRC64;
     MTEFDDCSHG ASNMYLPGCA YYVSPSDFST KPSFLSQSSS CQMTFPYSSN LPHVQPVREV
     AFREYGLERG KWQYRGSYAP YYSAEEVMHR DFLQPANRRT EMLFKTDPVC GHHGASPAAS
     NFYGSVGRNG ILPQGFDQFY EPAPAPPYQQ HSEGEGDADK GELKPQHSAC SKAPSGQEKK
     VTTASGAASP PGEAVAEKSN SSAVPQRSRK KRCPYTKYQI RELEREFFFN VYINKEKRLQ
     LSRMLNLTDR QVKIWFQNRR MKEKKLNRDR LQYFTGNPLF
//
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