ID   I0B176_9REOV            Unreviewed;       172 AA.
AC   I0B176;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=NSP4 {ECO:0000313|EMBL:AFH55336.1};
DE   Flags: Fragment;
OS   Rotavirus A.
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Sedoreoviridae; Rotavirus.
OX   NCBI_TaxID=28875 {ECO:0000313|EMBL:AFH55336.1};
RN   [1] {ECO:0000313|EMBL:AFH55336.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RVA/Human-wt/BFA/238-BF/2010/G6P[6]
RC   {ECO:0000313|EMBL:AFH55336.1};
RX   PubMed=22469076; DOI=10.3201/eid1804.110973;
RA   Nordgren J., Nitiema L.W., Sharma S., Ouermi D., Traore A.S., Simpore J.,
RA   Svensson L.;
RT   "Emergence of Unusual G6P[6] Rotaviruses in Children, Burkina Faso, 2009-
RT   2010.";
RL   Emerg. Infect. Dis. 18:589-597(2012).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JN116549; AFH55336.1; -; Genomic_RNA.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.430; -; 1.
DR   HAMAP; MF_04091; ROTA_NSP4; 1.
DR   InterPro; IPR002107; Rotavirus_NSP4.
DR   Pfam; PF01452; Rota_NSP4; 1.
DR   SUPFAM; SSF58030; Rotavirus nonstructural proteins; 1.
PE   3: Inferred from homology;
KW   Activation of host autophagy by virus {ECO:0000256|ARBA:ARBA00023050};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Enterotoxin {ECO:0000256|ARBA:ARBA00022861};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00023050};
KW   Membrane {ECO:0000256|SAM:Phobius}; Toxin {ECO:0000256|ARBA:ARBA00022656};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        26..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   COILED          82..109
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFH55336.1"
SQ   SEQUENCE   172 AA;  20073 MW;  44A9E90F0F725561 CRC64;
     LTDLNYTLSV ITLMNDTLHT ILEDPGMAYF PYIASVLTVL FTLHKASIPT MKIALKTSNC
     SYKVVKYCIV TIFNTLLKLA GYKEQITTKD EMEKQMDRVV KEMRRQLEMI DKLTTREIEQ
     VELLKHIYDK LMVRSNIEID MTKEINQKNV RTLEEWESGK NPYEPREVTA AM
//