ID   I0DCQ0_HBV              Unreviewed;       671 AA.
AC   I0DCQ0;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE   Flags: Fragment;
GN   Name=P {ECO:0000313|EMBL:AFH87381.1};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:AFH87381.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:AFH87381.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=478-0079-4 {ECO:0000313|EMBL:AFH87381.1};
RX   PubMed=22293432; DOI=10.1093/infdis/jir862;
RG   NHLBI-REDS-II Study Group;
RA   Delwart E., Slikas E., Stramer S.L., Kamel H., Kessler D., Krysztof D.,
RA   Tobler L.H., Carrick D.M., Steele W., Todd D., Wright D.J., Kleinman S.H.,
RA   Busch M.P.;
RT   "Genetic diversity of recently acquired and prevalent HIV, hepatitis B
RT   virus, and hepatitis C virus infections in US blood donors.";
RL   J. Infect. Dis. 205:875-885(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
CC   -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC       {ECO:0000256|ARBA:ARBA00007994}.
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DR   EMBL; JN604171; AFH87381.1; -; Genomic_DNA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001462; DNApol_viral_C.
DR   InterPro; IPR000201; DNApol_viral_N.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00336; DNA_pol_viral_C; 1.
DR   Pfam; PF00242; DNA_pol_viral_N; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          333..576
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          200..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        200..218
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFH87381.1"
FT   NON_TER         671
FT                   /evidence="ECO:0000313|EMBL:AFH87381.1"
SQ   SEQUENCE   671 AA;  75548 MW;  B688212EE963E7E9 CRC64;
     LPRLADEDLN RRVAEDLNLG NLNVSIPWTH KVGNFTGLYS STVPIFNPEW QTPSFPKIHL
     HEDIANRCQQ FVGPLTVNEK RRLKLIMPAR FYPNSTKYLP LDKGIKPYYP DHVVNHYFQT
     RHYLHTLWKA GILYKRETTR SASFCGSPYS WEQELHHGRL VIKTSQRHGD EPFCSQPSGI
     LSRSSVGPCI RSQFKQSRLG LQPHQGPLAT SQPGRSGSIR ARVHSPTRRC FGVEPSGSGH
     IGHSASSASS CLHQSAVRKA AYSHLSTSKR QSSSGHAVEF HSFPPSSARS QSQGPVFSCW
     WLQFRNTQPC SNYCLSHIVN LLEDWGPCAE HGEHHIRIPR TPARVTGGVF LVDKNPHNTA
     ESRLVVDFSQ FSRGITRVSW PKFAVPNLQS LTNLLSSNLS WLSLDVSAAF YHIPLHPAAM
     PHLLIGSSGL SRYVARLSSN SRINNNQHGT LQNLHDSCSR QLYVSLMLLY KTYGWKLHLY
     SHPIILGFRK IPMGVGLSPF LLAQFTSAIC SVVRRAFPHC LAFSYMDDVV LGAKSVQHLE
     SLYTAVTNFL LSLGIHLNPN KTKRWGYSLN FMGYVIGSWG TLPQDHIVQK IKHCFRKLPV
     NRPIDWKVCQ RIVGLLGFAA PFTQCGYPAL MPLYACIQAK QAFTFSPTYK AFLSKQYMNL
     YPVARQRPGL C
//