ID   I0DCS0_HBV              Unreviewed;       671 AA.
AC   I0DCS0;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE   Flags: Fragment;
GN   Name=P {ECO:0000313|EMBL:AFH87401.1};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:AFH87401.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:AFH87401.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=478-2959-6 {ECO:0000313|EMBL:AFH87401.1};
RX   PubMed=22293432; DOI=10.1093/infdis/jir862;
RG   NHLBI-REDS-II Study Group;
RA   Delwart E., Slikas E., Stramer S.L., Kamel H., Kessler D., Krysztof D.,
RA   Tobler L.H., Carrick D.M., Steele W., Todd D., Wright D.J., Kleinman S.H.,
RA   Busch M.P.;
RT   "Genetic diversity of recently acquired and prevalent HIV, hepatitis B
RT   virus, and hepatitis C virus infections in US blood donors.";
RL   J. Infect. Dis. 205:875-885(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
CC   -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC       {ECO:0000256|ARBA:ARBA00007994}.
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DR   EMBL; JN604176; AFH87401.1; -; Genomic_DNA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001462; DNApol_viral_C.
DR   InterPro; IPR000201; DNApol_viral_N.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00336; DNA_pol_viral_C; 1.
DR   Pfam; PF00242; DNA_pol_viral_N; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          333..576
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          200..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        200..217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFH87401.1"
FT   NON_TER         671
FT                   /evidence="ECO:0000313|EMBL:AFH87401.1"
SQ   SEQUENCE   671 AA;  75781 MW;  97101D828E40C565 CRC64;
     LPRLADADLN RRVAEDLNLG NLNVSIPWTH KVGNFTGLYS SXXPIFNPEW QTPSFPKIHL
     QEDIINRCQQ FVGPLTVNEK RRLKLIMPAR FYPXHTKYLP LDKGIKPYYP DQVVNHYFQT
     RHYLHTLWKA GILYKRETTR SASFCGSPYS WEQELQHGRL VIKTSQRHGD ESFCSQPSGI
     LSRSSVGPCI RSQLKQSRLG LQPHQGPLAS SQPGRSGSIR ARAHPSTRRY FGVEPSGSGH
     IDHSVNNSSS CLHQSAVRKA AYSHLSTSKR QSSSGHAVEF HCLPPSSAGS QSQGSVFSCW
     WLQFRNSKPC SEYCLSHIVN LREDWGPCDE HGEHHIRIPR TPARVTGGVF LVDKNPHNTE
     ESRLVVDFSQ FSRGXTRVSW PKFAVPNLQS LTNLLSSNLS WXSLDVSAAF YHIPLHPAAM
     PHLLIGSSGL SRYVARLSSN SRINNNQYGT MQNLHDSCSR QLYVSLMLLY KTYGWKLHLY
     SHPIVLGFRK IPMGVGLSPF LLAQFTSAIC SVVRRAFPHC LAFSYMDDVV LGAKSVQHLZ
     SLXTAVTNFL LSLGIHLNPN KTKRWGYSLN FMGYIIGSWG TLPQDHIVQK IKHCFRKLPV
     NRPIDWKVCQ RIVGLLGFAA PFTQCGYPAL MPLYACIQAK QAFTFSPTYK AFLRQQYMNL
     YPVARQRPGL C
//