ID   I0DD90_HBV              Unreviewed;       671 AA.
AC   I0DD90;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE   Flags: Fragment;
GN   Name=P {ECO:0000313|EMBL:AFH87571.1};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:AFH87571.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:AFH87571.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=477-4136-0 {ECO:0000313|EMBL:AFH87571.1};
RX   PubMed=22293432; DOI=10.1093/infdis/jir862;
RG   NHLBI-REDS-II Study Group;
RA   Delwart E., Slikas E., Stramer S.L., Kamel H., Kessler D., Krysztof D.,
RA   Tobler L.H., Carrick D.M., Steele W., Todd D., Wright D.J., Kleinman S.H.,
RA   Busch M.P.;
RT   "Genetic diversity of recently acquired and prevalent HIV, hepatitis B
RT   virus, and hepatitis C virus infections in US blood donors.";
RL   J. Infect. Dis. 205:875-885(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
CC   -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC       {ECO:0000256|ARBA:ARBA00007994}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JN604221; AFH87571.1; -; Genomic_DNA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001462; DNApol_viral_C.
DR   InterPro; IPR000201; DNApol_viral_N.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00336; DNA_pol_viral_C; 1.
DR   Pfam; PF00242; DNA_pol_viral_N; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          333..576
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          191..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        191..214
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFH87571.1"
FT   NON_TER         671
FT                   /evidence="ECO:0000313|EMBL:AFH87571.1"
SQ   SEQUENCE   671 AA;  75329 MW;  BA3C0C1D3B5066AA CRC64;
     LPRLADEGLN RRVAEDLNLG NLNVSIPWTH KVGNFTGLYS STVPNFNPDW QTPSFPDIHL
     QEDIVDRCKQ FVGPLTVNEI RRLKLIMPAR FYPNVTKYLP LDKGIKPYYP EHVVNHYFQT
     RHYLHTLWKA GILYKRETTR SASFCGSPYS WEQELQHGRL VFQTSKRHGD KSFCPQSTGI
     LPRSSVGPCI QSQLRKSRLG PQSTQGQLAG RQQGGSGSIR ARVHPSPWGP VGVEPSGSGH
     THNCASSTSS XLHQSAVRKA AYSLISTSKG HSPSGXAVEL HHXPSNSSRS QSQGSVLSCW
     WLQFRNSEPC SEYCLCHIIN LLEDWGPCTE HGEHRIRTPR TPARVTGGVF LVDKNPHNTT
     ESRLVVDFSQ FSRGNTRVSW PKFAVPNLQS LTNLLSSNLS WLSLDVSAAF YHLPLHPAAM
     PHLLVGSSGL SRYVARLSSN SRIIBHQHRT MQNLHDSCSR NLYVSLMLLY KTYGRKLHLY
     SHPIILGFRK IPMGVGLSPF LLAQFTSAVC SVVRRAFPHC LAFSYMDDVV LGAKSVQHLE
     SLYAAVTNFL LSLGIHLNPH KTKRWGYSLN FMGYVIGSWG SLPQEHIVQK IKSCFRKLPV
     NRPIDWKVCQ RIVGLLGFAA PFTQCGYPAL MPLYACIQAK QAFTFSPTYK AFLSKQYLNL
     YPVARQRPGL C
//