ID   I0DDR7_HBV              Unreviewed;       671 AA.
AC   I0DDR7;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE   Flags: Fragment;
GN   Name=P {ECO:0000313|EMBL:AFH87748.1};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:AFH87748.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:AFH87748.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=476-6804-3 {ECO:0000313|EMBL:AFH87748.1};
RX   PubMed=22293432; DOI=10.1093/infdis/jir862;
RG   NHLBI-REDS-II Study Group;
RA   Delwart E., Slikas E., Stramer S.L., Kamel H., Kessler D., Krysztof D.,
RA   Tobler L.H., Carrick D.M., Steele W., Todd D., Wright D.J., Kleinman S.H.,
RA   Busch M.P.;
RT   "Genetic diversity of recently acquired and prevalent HIV, hepatitis B
RT   virus, and hepatitis C virus infections in US blood donors.";
RL   J. Infect. Dis. 205:875-885(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
CC   -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC       {ECO:0000256|ARBA:ARBA00007994}.
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DR   EMBL; JN604269; AFH87748.1; -; Genomic_DNA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001462; DNApol_viral_C.
DR   InterPro; IPR000201; DNApol_viral_N.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00336; DNA_pol_viral_C; 1.
DR   Pfam; PF00242; DNA_pol_viral_N; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          333..576
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          196..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        196..217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFH87748.1"
FT   NON_TER         671
FT                   /evidence="ECO:0000313|EMBL:AFH87748.1"
SQ   SEQUENCE   671 AA;  75634 MW;  24CBB531BC26C4A6 CRC64;
     LPRLADADLN RRVAEDLNLG NLNVSIPWTH KVGNFTGLYS STVPIFNPEW QTPSFPRIHL
     QEDIINRCQQ FVGPLTANEK RRLKLIMPAR FYPNHTKYLP LDKGIKPYYP DQVVNHYFQT
     RHYLHTLWKA GILYKRETTR SASFCGSPYS WEQELQHGRL VIKTSQRHGD ESFCSQPSGI
     LSRSSVGPCI RSQLKQSRLG LQPHQGPLAS SQPGRSGSIR ARAHPSTRRY FGVEPSGSGH
     IDHSVNNSSS CLHQSAVRKA AYSHLSTSKR QSSSGHAVEF HCLPPSSAGS QSQGSISSCW
     WLQFRDSKPC SEYCLSHLVN LREDWGPCDE HGEHHIRIPR TPARVTGGVF LVDKNPHNTA
     ESRLVVDFSQ FSRGITRVSW PKFAVPNLQS LTNLLSSNLS WLSLDVSAAF YHIPLHPAAM
     PHLLIGSSGL SRYVARVSSN SRINNNQYGT MQNLHDSCSR QLYXSLMLLY KTYGWKLHLY
     SHPIVLGFRK IPMGVGLSPF LLAQFTSAIC SVVRRAFPHC LAFSYMDDVV LGAKSVQHRE
     ALYTAVTNFL LSLGIHLNPN KTKRWGYSLN FMGYIIGSWG TLPQDHIVQK IKHCFRKLPV
     NRPIDWKVCQ RIVGLLGFAA PFTQCGYPAL MPLYACIQAK QAXTFSPTYK AFLSKQYMNL
     YPVARQRPGL C
//