ID I0EI71_HELPX Unreviewed; 678 AA.
AC I0EI71;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=HPPC18_04475 {ECO:0000313|EMBL:AFI02640.1};
OS Helicobacter pylori PeCan18.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1163742 {ECO:0000313|EMBL:AFI02640.1, ECO:0000313|Proteomes:UP000005006};
RN [1] {ECO:0000313|EMBL:AFI02640.1, ECO:0000313|Proteomes:UP000005006}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PeCan18 {ECO:0000313|EMBL:AFI02640.1,
RC ECO:0000313|Proteomes:UP000005006};
RA Kersulyte D., Ramirez Ramos A., Recarvarren S., Barua R.L., Watanabe J.,
RA Gilman R.H., Berg D.E.;
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP003475; AFI02640.1; -; Genomic_DNA.
DR RefSeq; WP_000894604.1; NC_017742.1.
DR AlphaFoldDB; I0EI71; -.
DR KEGG; hca:HPPC18_04475; -.
DR PATRIC; fig|1163742.3.peg.918; -.
DR HOGENOM; CLU_004585_5_10_7; -.
DR Proteomes; UP000005006; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 5..278
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 279..597
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 26..33
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 678 AA; 76940 MW; F83F808C36904C1C CRC64;
MLETLQLNPE QLKAASALQG HNLVIASAGT GKTSTIVGRI LHLLDNGIKP EEILLLTFTN
KASNEMIARV AKYSKLSSKI EAGTFHAVAY RYLKEHYPNL SLKQPKELRK LLESIVDTKN
ALNATDEDKR PYTSQHLYAL YSLYTNALKQ EDFSAWLSSK NPEHAPYAAF YENILDEFEN
TKKKHDYIDY NDLLLLFKKA MLERPSPYKE VLCDEFQDTN PLQESILDAI NPPSLFCVGD
YDQSIYAFNG ADISIISNFT QKYKNARVFT LTKNYRSSKE ILDLANQVIQ HNQRIYPKNL
EVVKSGKFNK PTLLNYNDNI AQCQDIAKRI VMRKDFKEVA VIFRNNASAD QLEAALRSHN
VPSKRKGSAS FFESKEVALT LDICALLFNP KDIMAAIHIL SYISDIGSNT AKDIHEALML
LGNGDLKLAL TQPNQEAKIY TKKKEITSMG LFEEIFALEN SSRFNSVIDK AFHSHPVLMH
PKISLNGAKT LSDFFILYTK APTHSPSALI KHILESAFFQ TFKTRLLKER SKNKDGSYNE
FKKLQAQKRF NEKMDLLSSL AKNYQNLGRF LNGTLIGSNE ATQGEGVNLL SVHASKGLEF
KDVYIIDLME GRFPNHKLMN TGGGIEEERR LFYVAITRAK ENLWLSYAKN ELRENAKPKE
HKPSVFLYEA GLLKLDSK
//
